How to take nimesil correctly. How to take Nimesil powder and what is it for? Nimesil - description, therapeutic effect

• Latin name: Nimesil
• ATX code: M01AX17
• Active substance: Nimesulide (Nimesulide)
• Manufacturer: Laboratorios MENARINI (Spain)

Composition of Nimesil

The preparation contains nimesulide in the amount of 100 mg per 1 sachet.

Additional substances: sucrose, ketomacrogol, citric acid, orange flavor, maltodextrin.

Release form

The medicine Nimesil is a granule for the manufacture of oral suspension in the form of a light yellow powder with an orange smell.

• 2 grams of Nimesil in a paper bag;
• 9, 30 or 15 sachets in a carton.

pharmachologic effect

Antipyretic, anti-inflammatory, analgesic effect.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Anti-inflammatory nonsteroidal drug from the group sulfonamides . It has anti-inflammatory, antipyretic and analgesic effects.

Wikipedia indicates that the active substance acts as a blocker cyclooxygenase type II responsible for biosynthesis.

Pharmacokinetics

After administration, it is well absorbed in the intestine, reaching the highest concentration in 2-3 hours later. Reaction with plasma proteins is 97.5%. The half-life is 4-5 hours. Quickly penetrates through histohematic barriers.

Transformed in the liver by cytochrome P450 . The main active is hydroxynimesulide , which is excreted in the bile in a glucuronidated form. Excreted from the body, mainly by the kidneys (about half of the accepted dose).

Indications for the use of Nimesil powder

The drug serves for symptomatic therapy, relief of inflammation and pain at the time of use.

Indications for Nimesil's use:

• symptomatic therapy of pain syndrome against the background;
• relief of acute pain (pain in the lower back and back; pain syndrome in trauma, tendonitis , sprains and dislocations; toothache);
• algomenorrhea .

Contraindications for Nimesil

Contraindications for use:

• hepatotoxic reactions , caused by the active substance in history;
• bronchospasm associated with the use or other in history;
• co-administration of drugs with potential hepatotoxicity;
• condition after coronary artery bypass grafting ;
• inflammatory bowel disease ( nonspecific ulcer, Crohn's disease ) in the acute stage;
• an increase in body temperature in diseases of an infectious and inflammatory nature;
• exacerbation, history, perforation or bleeding in the organs of the digestive tract;
• combination , nasal polyposis and intolerance non-steroidal anti-inflammatory drugs ;
• bleeding of cerebrovascular or other localizations; diseases accompanied by pathological bleeding;
• decompensated heart failure ;
• severe disorders of blood coagulation;
• decompensated, hyperkalemia ;
• liver disease;
• liver failure;
• , drug addiction;
• or ;
• age under 12;
• to the ingredients of the drug.

The abstract recommends using Nimesil with caution if severe forms are present. second type or ; ischemic disease, heart failure, dyslipidemia , cerebrovascular disease, peripheral arterial disease, elderly age; peptic ulcer in the past, infections associated with Helicobacter pylori; prolonged prior use non-steroidal anti-inflammatory drugs ; decompensated somatic diseases; smoking and concomitant medication anticoagulants, oral glucocorticosteroids, antiplatelet agents, selective serotonin reuptake blockers.

Side effects

Treatment of overdose is symptomatic. There is no electoral. If no more than 4 hours have passed since the overdose, it is necessary to wash the stomach and provide enterosorbenes what is used or osmotic laxative . Shows control over the work of the kidneys and liver.

Interaction

When used simultaneously with glucocorticosteroids increases the risk of ulcers or bleeding from the stomach and intestines.

When used with antiplatelet agents and selective reuptake inhibitors it also increases the chance of bleeding from the stomach or intestines.

may enhance the effects anticoagulants therefore, this combination is not recommended for persons with severe disorders coagulation . If this combination still can not be avoided, it is necessary to carefully monitor the parameters of blood clotting.

Anti-inflammatory nonsteroidal drugs able to mitigate the effects diuretics .

Nimesulide able to temporarily reduce evacuation sodium and potassium under the influence and thereby weaken the diuretic effect of the latter. It must also be remembered that such co-administration of drugs requires caution in individuals with impaired renal and cardiac function.

Anti-inflammatory nonsteroidal drugs may weaken the effect antihypertensive drugs . In persons with compensated kidney failure with simultaneous appointment ACE blockers ,type 2 angiotensin receptor antagonists or means of suppressingcyclooxygenase , progression of deterioration in kidney function and the development of reversible kidney failure acute type.

Anti-inflammatory nonsteroidal drugs reduces ground clearance lithium , which causes an increase in the level of the latter in the blood.

When prescribing Nimesil less than a day before or after use, care must be taken, since in such cases the content Methotrexate in the blood and its toxic effects may increase.

Nimesulide can stimulate nephrotoxicity cyclosporins .

Terms of sale

Without recipe.

Storage conditions

Store in a dry, dark place at room temperature. Keep away from children.

Best before date

special instructions

Side effects can be minimized by using the lowest effective dosage of the drug for the shortest possible course.

The medicine in Nimesil powder should be used with caution in individuals with a history of gastrointestinal diseases, since an exacerbation of these diseases is not excluded.

Since the drug is partially evacuated by the kidneys, its dosage for people with impaired renal function should be reduced depending on the amount of urination.

When the first symptoms of liver damage appear (itching, yellowing of the skin, nausea, abdominal pain, vomiting, dark urine, an increase in the content of "liver" transaminases), it is necessary to stop taking the medication and consult a doctor.

If any signs of visual impairment appear during drug therapy, the patient should be examined by an ophthalmologist.

Nimesil is able to provoke fluid retention in the body, so people with high blood pressure and heart disease should use the drug with extreme caution.

If symptoms of an acute respiratory infection of a viral nature occur during drug therapy, Nimesil should be stopped.

Nimesil should not be used simultaneously with other anti-inflammatory nonsteroidal drugs .

Nimesulide is able to change the characteristics, so care must be taken when using the drug in patients with hemorrhagic diathesis . It is worth remembering that the medicine does not replace the preventive effect. acetylsalicylic acid in diseases of the circulatory system.

Nimesil's analogs

The price of Nimesil analogues is usually lower than that of the described remedy. The following are drugs with an identical composition, which can replace Nimesil: Ameolin (tablets), (tablets), Affida Fort (granules for suspension), Mesulid (tablets), (tablets, suspension), Negan (tablets), (tablets, suspension), Nimesin (tablets), (tablets, gel), (tablets, granules), Nimujet (injection solution), (tablets, suspension, injection solution, gel), Nimuspaz (tablets), Pansulid (tablets), Remesulid (tablets), Sulidin (gel), Taro-Sanovel (tablets).

Nise or Nimesil - which is better?

nise and Nimesil are analogues. The main difference between the drugs is that the first is available in the form of a gel for topical use and tablets, and the cost Naiza an order of magnitude lower. The choice should be made based on the recommendations of the doctor, the type of indication and economic considerations.

Nimesil for children

Nimesil (like tablets or ointment based on nimesulide ) should not be used in children under 12 years of age. The instruction for the drug for children indicates that the method of using Nimesil (how to use and how to dilute the powder) in the rest age groups is not different. How to use the powder, how to dilute Nimesil in powder, and how to drink Nimesil in powder, is described in the section "Instructions for using Nimesil (Method and dosage)"

Can Nimesil be given to children at a temperature?

This medicine is not the drug of choice for lowering body temperature, although it has a mild antipyretic effect. Nimesil should be used only for the purpose of stopping mild and moderately mild pain. Prohibited for the treatment of children under 12 years of age.

Alcohol compatibility

Nimesil and alcohol are incompatible, since both substances are hepatotoxic. Their simultaneous use can lead to severe disorders of the liver and irreversible consequences, especially against the background of already present diseases of the hepatobiliary system.

Nimesil during pregnancy and lactation

Use of the drug during pregnancy or breastfeeding is strictly prohibited, as nimesulide and others anti-inflammatory nonsteroidal drugs can adversely affect the course of pregnancy and the development of the child.

The drug Nimesil is designed to relieve severe pain and fever, has anti-inflammatory drugs, the spectrum of its clinical effects is very wide. It can be used both for a long course of treatment, and for a one-time relief of sharp pains. The drug does not belong to the group of antibiotic drugs, is not an antibacterial agent, with prolonged use usually does not cause side effects and is easily tolerated by the body.

Reviews of doctors about the drug describe Nimesil as a good remedy that effectively relieves painful symptoms of a traumatic nature and reduces pain in the musculoskeletal system. And also it is often prescribed for toothaches, headaches and menstrual pains. However, it is worth remembering that drugs whose active ingredient is banned for use in several countries due to its increased hepatotoxic effect.

Nimesil: description

The drug looks like a light yellow powder with an orange aroma.

The price of the drug depends on the size of the box. On sale are packages of nine, fifteen or thirty bags. The price of one bag varies from twenty-two to forty rubles.

Depending on the volume of packaging and the region of residence, the price may go beyond these limits.

The drug is dispensed in pharmacies without a prescription, is not intended for treatment without the participation of a doctor.

Powder Nimesil: composition

Powder Nimesil: indications for use

This analgesic, anti-inflammatory and antipyretic drug is prescribed for a very wide range of diseases, as it is extremely effective as a pain reliever.

Nimesil is intended for symptomatic treatment, reducing pain and inflammation for the period of use. The drug is prescribed for the following diseases and pathologies:

• Acute pain in the dorsal and lumbar regions;
• Pain in bones and muscles
• Post-traumatic pain (sprains, dislocations);
• toothache, caries, pulpitis;
• Painful sensations during the menstrual period;
• In the treatment of osteoarthritis;
• Tendinitis;
• Bursitis;
• Algodysmenorrhea syndrome.

It is important to remember that the main goal of taking the drug is to reduce acute pain and relieve symptoms. It does not play a role in the treatment of the disease, which led to painful sensations and inflammatory processes.

Nimesil powder: instructions for use

To reduce the risk of side effects, you must take the drug strictly according to the instructions, after a preliminary consultation with your therapist. A qualified specialist will correctly determine the required dosage and, if necessary, adjust the instructions for use.

• The contents of the sachet are poured into a glass and dissolved in about one hundred milliliters of warm boiled water.
• Suggested Time of Use: Twice a day after meals.
• The finished solution can not be stored, so the drug should be used immediately after dilution.

• The best effect of the drug is achieved after about two to three hours after use.
• The drug is well absorbed, half-excreted from the body in four to five hours.
• The maximum course of treatment does not exceed fifteen days.
• To reduce the risk of overdose and side effects, it is necessary to use the drug in the minimum dosage in the shortest possible time period.

Dosage

• The drug is contraindicated in children, it is used only for the treatment of persons over twelve years of age.
• Patients aged 12 to 18 years use Nimesil in a standard dosage.
• For the treatment of the elderly, a dose adjustment is necessary, which is determined by the therapist, based on the interaction of the active substance with other drugs that the patient is taking.
• For people with mild to moderate renal impairment, there is no need to change the standard dosage. With more serious deviations, the use of the drug is contraindicated.

Overdose

In case of an overdose of the drug, the following side effects may occur:

• Drowsiness, state of weakness, apathy;
• Disorders of the stomach, abdominal pain. In rare cases, bleeding in the stomach may occur;
• Nausea, vomiting;
• A sharp increase in pressure;
• Exacerbation in patients with renal insufficiency;
• breathing difficulties;
• Coma;
• Anaphylactic shock.

If the therapeutic dose was small, then these side effects are reversible. In other cases, the attending physician prescribes treatment, depending on the symptoms manifested.

In the event that no more than four hours have passed since the beginning of the excess dosage and the onset of its symptoms, then you need to clear the stomach. First you need to induce a gag reflex, and then take a laxative or activated charcoal to remove toxins from the body.

Powder Nimesil: side effects

Usually, the use of Nimesil powder is well tolerated by the internal organs, however, if the dosage is violated and at the beginning of the course of treatment, the following side effects may occur:

• Disorders in the circulatory system: anemia, thrombocytopenia and others.
• Allergic reactions of a different nature;
• Problems in the central nervous system: headaches, sleep problems, baseless feelings of anxiety and fear.
• Minor blurred vision;
• Labored breathing, shortness of breath;
• Increasing pressure, arrhythmia;
• Problems in the digestive system: stomach pain, nausea and vomiting, constipation or diarrhea, exacerbation of gastritis, peptic ulcers;
• Violations in the functioning of the urinary system, kidney failure.

People who have health problems should use this drug carefully, as it can provoke exacerbations of diseases. Particular attention should be paid to people with diseases of the liver and kidneys, since Nimesil has an increased effect on these organs.

In case of exacerbation of old diseases and the occurrence of deviations, it is necessary to stop using the drug and consult your doctor to relieve symptoms.

Nimesil: contraindications for use

• For children under the age of 12;
• High sensitivity to the active substance (nimesulide) or additional substances;
• Allergic reactions to the active substance or components;
• Hepatological reactions of the body to the active ingredient in history;
• Treatment with drugs that have hepatoxic effects;
• With exacerbations of inflammatory intestinal processes;
• The period of rehabilitation after heart bypass surgery;
• Fever associated with colds and SARS;
• An ulcer of the stomach or duodenum in the acute stage;
• Bleeding with ulcers and caused by other diseases;
• Poor blood clotting;
• Severe stages of heart and kidney failure;
• Increased potassium in the blood;
• Liver disease in severe stages and liver failure;
• Pregnancy and lactation period;
• Alcohol and drug addictions.

Powder Nimesil during pregnancy and lactation

The drug is prohibited for use by pregnant and lactating women, since the active ingredient in Nimesil, nimesulide, can have an extremely negative effect on the course of pregnancy and the intrauterine development of the baby. The use of Nimesil during pregnancy can lead to early closure of the ductus arteriosus, hypertension in the pulmonary artery, renal failure, a high risk of bleeding, decreased uterine contraction, peripheral edema of varying severity and other undesirable effects.

Also, Nimesil is highly advised not to use for women who are just planning a pregnancy, as the drug negatively affects fertility and can affect the process of conceiving a child.

Nimesil is an antipyretic, analgesic, anti-inflammatory agent. Belongs to the class of sulfonamides, the category of non-narcotic analgesics. Instructions for use Nimesil indicates a wide range of its clinical effects. The powder effectively fights fever, rheumatism, it is prescribed for neuralgia, bursitis, it is able to eliminate pain syndromes associated with injuries of soft tissues and the musculoskeletal system. The balanced composition of the drug allows it to be used both for long-term therapy and for course symptomatic treatment or a single use in order to relieve severe pain.

The price of Nimesil depends on the manufacturer and type of packaging.

1. Pharmacological action

Therapeutic effects of Nimesil:

• analgesic action;
• Anti-inflammatory action;
• Antipyretic action.

Plasma protein binding: significant.

2. indications for use

• toothache;
• pain during menstruation;
• postoperative pain;
• headaches;
• pain after various injuries;
• pain syndrome of high severity;
• inflammation after surgery;
• inflammation after various injuries;

• arthritis;
• osteochondrosis;
• radiculitis;
• rheumatism;
• various gynecological diseases;
• various urological diseases;
• various vascular diseases;
• various diseases that lead to an increase in body temperature.

3. How to use

Application Features:
Simultaneous use of Nimesil with Hydantoin or drugs from the group of sulfonamides should take place under the close supervision of specialists.

4. Side effects

• Hematopoietic system: increase in the number of eosinophils, decrease in the number of red blood cells, decrease in the number of all blood cells, decrease in the number of platelets;
• Liver and biliary tract: the appearance of jaundice, stagnation of bile, increased activity of liver enzymes, inflammation of the liver;
• Respiratory system: shortness of breath, bronchial spasm;
• Digestive system: vomiting, ulcerative lesions of the digestive system, inflammation of the stomach, nausea, diarrhea, bleeding from the stomach, bleeding from the intestines, constipation, gastric perforation, intestinal perforation;
• Central nervous system: headaches, multiple disruption of the activity of all parts of the brain, nervousness, the appearance of nightmares, dizziness, drowsiness, causeless fear;
• Urinary system: violation of urination, the appearance of blood in the urine, functional insufficiency of the normal activity of the kidneys, urinary retention, lack of urination, inflammation of the kidneys;
• Damage to the skin: rashes, redness of the skin, dermatitis, swelling, itching of the skin, excessive sweating;
• Sense organs: impaired visual perception;
• Cardiovascular system: cardiac arrhythmias, sensation of hot flashes, increased levels of total arterial pressure, hemorrhages.

5. Contraindications

6. During pregnancy and lactation

Nursing mothers can take Nimesil only in case of complete rejection of breastfeeding.

7. Interaction with other drugs

• drugs that reduce the ability of blood to clot or lead to an increase in their action;
• Methotrexate leads to side effects;
• Cyclosporine leads to an increase in the action of Cyclosporine directed to the kidneys;
• medicines containing lithium leads to an increase in the concentration of lithium in the blood.

8. Overdose

• Digestive system: the appearance of vomiting, the appearance of nausea, the appearance of bleeding from the organs of the digestive system;
• Central nervous system: apathy, drowsiness.

Overdose treatment:

• Stopping taking Nimesil;
• Urgent gastric lavage;
• Reception of enterosorbents in the maximum possible dosage;
• symptomatic treatment;
• Supportive care.

9. Release form

10. Storage conditions

• Lack of access to light;
• Lack of access for children;
• Normal level of humidity of the surrounding air;
• Lack of access by unauthorized persons.

11. Composition

1 bag of granules:

• nimesulide - 100 mg;
• Excipients: ketomacrogol 1000, sucrose, maltodextrin, anhydrous citric acid, orange flavor.

12. Terms of dispensing from pharmacies

The substances that make up Nimesil effectively cope with any inflammation. At first glance, the inflammatory process is even beneficial for the body - it increases the general and local body temperature, which kills pathogenic microorganisms. However, any inflammation causes swelling of the surrounding tissues - they, in turn, compress the nerve endings, which causes severe and often prolonged pain. This is especially dangerous when inflammation does not indicate recovery, but is an additional symptom in a number of autoimmune or infectious-inflammatory diseases.

The unique composition of Nimesil powder makes it an effective anti-inflammatory agent. Instructions for use of the drug indicates that it is ideal for such cases.

The method of application of Nimesil depends on the cause of the pain syndrome. The drug is also used:

• with postoperative pain;
• for the treatment of various gynecological, urological, vascular diseases;
• to eliminate inflammation after various injuries, etc.

Before using the medicine, it is necessary to study the instructions for use of Nimesil powder (nimesil). Non-hormonal anti-inflammatory drugs, to which it belongs, are not suitable for frequent use. A long course and the wrong way of taking it can cause unpleasant side effects, often life-threatening. A safe way is to take the powder in short courses or in rare cases. So you can completely eliminate pain and improve the course of any disease. The current prices for medicines, including the price of Nimesil, are presented on the website.

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* Instructions for medical use for the drug Nimesil published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, IT IS NECESSARY TO CONSULT WITH A SPECIALIST

Anti-inflammatory drugs are widely used among the population, which is associated with frequent illnesses and over-the-counter dispensing. At the same time, few people know that even such common medicines cause the development of unpleasant symptoms associated with an overdose. One of the most popular anti-inflammatory drugs is Nimesil, available under various trade names (.).

An overdose of Nimesil leads to the appearance of severe symptoms associated with impaired functioning of the kidneys, liver and gastrointestinal tract, which is observed with uncontrolled intake of tablets. In this regard, it is recommended for everyone to know the symptoms of poisoning, to be able to provide first aid.

About the drug: mechanism of action and indications

Nimesil is a bright representative of the group of non-steroidal anti-inflammatory drugs (NSAIDs), which has a pronounced analgesic, anti-inflammatory effect, and a weak antipyretic effect. The main indications for the use of the drug are as follows:

• pain syndromes of various causation;
• pain in muscles, joints;
• diseases with an inflammatory component, including autoimmune ones;
• rise in body temperature.

Similar effects of Nimesil are associated with the ability to block the cyclooxygenase enzyme, which mediates the release of mediators associated with pain and inflammation.

The drug is available in various dosage forms: tablets for oral administration, granular powders, special tablets for children, suspensions. This allows you to choose the best way to use the medication for each person.

What are the contraindications?

An overdose of Nimesil is more often associated with the use of the drug against the background of existing contraindications:

• individual intolerance to the active substance or auxiliary components that make up the tablets, suspensions;
• allergic reactions to Nise and other NSAIDs;
• erosive, ulcerative diseases of the digestive system (chronic gastritis, peptic ulcer, ulcerative colitis);
• the presence of bronchial asthma, other severe allergic diseases;
• dysfunction of the kidneys, liver, including chronic renal and hepatic insufficiency;
• pathology of the blood coagulation system;
• nimesil is contraindicated in early pregnancy;
• nimesil in case of poisoning with other NSAIDs as an anesthetic drug is contraindicated;
• the patient's age is up to 12 years (see).

In the presence of any of these contraindications, the use of the drug is prohibited due to the high risk of overdose symptoms, various side effects from therapy.

Use of Nimesil: dosages and timing of administration

The best way to prevent overdose is to follow the instructions for use. The drug is used twice a day at a dose of 100 mg (regardless of dosage form). At the same time, it is better to drink Nimesil immediately after meals, to reduce the negative impact on the gastrointestinal tract.

Children under 12 years of age should not use the medicine. Many patients ask themselves: "How many days can I drink Nimesil?". The maximum duration of a course of treatment is 5-6 days, after which a break is taken in taking the drug to prevent the development of an overdose.

If the patient has diseases of the kidneys and liver, then the attending physician carefully monitors their functions, if necessary, interrupts therapy, while prescribing supportive treatment.

The main manifestations of an overdose

Poisoning with Nimesil leads to the development of unpleasant symptoms of varying severity: from mild discomfort to life-threatening conditions. Main manifestations:

1. On the part of the gastrointestinal tract, dyspeptic symptoms develop, including: nausea, vomiting, stool disorders. In severe overdose, ulceration and the onset of intragastric or intra-intestinal bleeding of varying intensity are observed.
2. From the side of the central nervous system, the patient has apathy, increased fatigue, constant drowsiness.
3. Patients with pre-existing hypertension develop hypertensive crises, which themselves can lead to complications.
4. Violations of liver function as a result of the action of Nimesil on liver cells.
5. On the part of the organs of the urinary system, the development of renal failure is noted.

If mild symptoms of poisoning are detected, the changes do not pose a serious threat to human health and life. However, it is important to remember that even the first manifestations (nausea, minor abdominal pain) develop into severe complications requiring hospitalization. Therefore, patients with symptoms of an overdose of Nimesil should be given first aid and examined by the attending physician.

First aid

There are no specific antidotes for overdose, so treatment at the pre-medical and medical stages is symptomatic. Necessary measures to be taken if a person has symptoms of Nimesil poisoning:

1. The first important step- complete until clean wash water is obtained. Manipulation is simple: the patient drinks from 1 to 2 liters of warm water, while the volume is calculated approximately for the age and weight of the person. After that, a gag reflex is caused, leading to emptying and gastric lavage. This action allows you to clear the stomach of the remnants of the drug, thereby reducing its further absorption.
2. Despite the effectiveness of washing, part of Nimesil overcomes the stomach, passes into the intestines before the start of first aid. These drug molecules must be bound in the intestinal lumen and removed from the body. For this purpose, enterosorbents are used ( Activated carbon, Enterosgel). Their dose is calculated in accordance with the instructions for use.
3. With severe vomiting or diarrhea, provide the patient with clean warm water to replenish the fluid lost from the body.

Everything about

Nimesil is an antipyretic, analgesic, anti-inflammatory agent. Belongs to the class of sulfonamides, the category of non-narcotic analgesics. Instructions for use Nimesil indicates a wide range of its clinical effects.

The balanced composition of the drug allows it to be used both for long-term therapy and for course symptomatic treatment or a single use in order to relieve severe pain.

In this article, we will consider why doctors prescribe Nimesil, including instructions for use, analogues and prices for this drug in pharmacies. If you have already used Nimesil, leave your feedback in the comments.

Release form and composition

Clinical and pharmacological group: NSAIDs, selective COX-2 inhibitor. Nimesil is available in the form of granules for the preparation of a suspension for oral use.

The active ingredient is nimesulide. The drug is produced in the form of packages of 2 grams, the number of packages in a package is 9, 15 and 30 pcs.

The quantitative content of the active substance in one sachet is 100 mg. The auxiliary substances are components such as sucrose, orange flavor, citric acid, ketomacrogol.

pharmachologic effect

Nimesil provides a pronounced analgesic, antipyretic and anti-inflammatory effect. The principle of operation of this product lies in the inhibition of the synthesis of prostaglandins. Nimesil inhibits the synthesis of prostaglandins at the site of inflammation more effectively than in the gastric mucosa or in the kidneys.

With long-term treatment, the product is fairly well tolerated. Its action develops relatively quickly, which is facilitated by the properties of the dosage form. The duration of the effect is approximately 6 hours.

Instructions for use

The drug is used only for the treatment of patients older than 12 years.

• Nimesil is taken orally, 1 sachet (100 mg of nimesulide) 2 times / day. The drug is recommended to be taken after meals. The contents of the sachet are poured into a glass and dissolved in about 100 ml of water. The prepared solution cannot be stored.
• The maximum duration of treatment with nimesulide is 15 days. To reduce the risk of unwanted side effects, the minimum effective dose should be used for the shortest possible course.

Adolescents (aged 12 to 18 years): based on the pharmacokinetic profile and pharmacodynamic characteristics of nimesulide, there is no need for dose adjustment in adolescents.

Elderly patients: in the treatment of elderly patients, the need to adjust the daily dose is determined by the doctor based on the possibility of interaction with other drugs.

Patients with impaired renal function: based on pharmacokinetic data, there is no need to adjust the dose in patients with mild to moderate renal insufficiency (CC 30-80 ml / min).

Contraindications

It is forbidden to use the drug in such cases:

1. Hepatotoxic reactions of the body to nimesulide in history.
2. Simultaneous treatment with other drugs that have a hepatotoxic effect (especially from the NPS group).
3. Inflammatory processes in the intestines in the acute phase (Krone's b-n, ulcerative colitis).
4. Recovery period after coronary artery bypass grafting.
5. Fever accompanying colds and SARS.
6. The combination of bronchial asthma, polyposis of the paranasal sinuses or nose with a recurrent course and intolerance to NSAIDs in history.
7. Hypersensitivity to the active base (nimesulide) or an auxiliary component of the drug.
8. History of hyperergic reactions of the body: rhinitis, urticaria, bronchospasm, laryngospasm associated with taking any drug from the NSAID group, including nimesulide.
9. Exacerbation of a stomach or duodenal ulcer;
10. An ulcer with a history of bleeding or perforation;
11. Cerebrovascular and other bleeding in history;
12. Renal failure in severe degree;
13. Confirmed hyperkalemia;
14. Liver disease in the acute phase;
15. Liver failure;
16. Diseases accompanied by bleeding;
17. Violation of blood clotting of a severe nature;
18. severe heart failure;
19. Pregnancy, lactation;
20. Children under 12;
21. Drug addiction, alcoholism.

With caution, Nimesil is prescribed for the following pathologies and factors:

• heart failure of any degree;
• severe arterial hypertension;
• type 2 diabetes mellitus;
• hereditary fructose intolerance;
• malabsorption of glucose-galactose;
• arterial disease (peripheral);
• infection caused by Helicobacter pylori;
• creatinine clearance less than 60 ml/min;
• long-term treatment with NSAIDs;
• insufficiency of sucrose-isomaltose;
• dis- or hyperlipidemia;
• cerebrovascular pathologies;
• severe somatic diseases;
• elderly age;
• smoking.

Pregnancy and lactation

Like other NSAIDs that inhibit prostaglandin synthesis, nimesulide may adversely affect pregnancy and/or fetal development and may lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired renal function, which may progress to renal failure. with oligodyramnia, to an increased risk of bleeding, a decrease in uterine contractility, the occurrence of peripheral edema. In this regard, the drug is contraindicated during pregnancy and during breastfeeding.

Side effects

When using this drug, the following side effects are possible:

1. Allergic manifestations - rash, itching, increased sweating, hypersensitivity, dermatitis, erythema, urticaria, anaphylactic shock, angioedema, Stevens-Johnson syndrome, Lyell's syndrome.
2. Hematopoietic system - anemia, hemorrhagic syndrome, eosinophilia, thrombocytopenic purpura, thrombocytopenia.
3. Digestive system - diarrhea, vomiting, nausea, constipation, gastritis, flatulence, abdominal pain, tarry stools, dyspepsia, stomatitis, stomach ulcers, gastric and intestinal bleeding, hepatitis, jaundice.
4. Central nervous system - nervousness, dizziness, fear, nightmares, headache, encephalopathy, drowsiness.
5. Organs of vision - fuzziness, foggy.
6. Cardiovascular system - hypertension, tachycardia, hot flashes, blood pressure lability.
7. Urinary system - hematuria, dysuria, urinary retention, oliguria, interstitial nephritis, renal failure.
8. Respiratory system - shortness of breath, bronchospasm, recession of bronchial asthma.

Most often, when using non-steroidal anti-inflammatory drugs (NSAIDs), there is a violation in the gastric tract. Clinical studies have shown that long-term use of NSAIDs (especially at high doses) can contribute to arterial thrombosis (myocardial infarction or stroke).

special instructions

Studies showing the ability to drive a car or other vehicles have not been conducted. If, however, while taking the medicine there is increased drowsiness and dizziness, you should refrain from driving vehicles and production machines.

If flu-like symptoms, severe dizziness, stomach pain, vomiting, dark urine occur while taking the drug, stop taking the drug, consult a doctor and switch to another group of painkillers and anti-inflammatory drugs.

Overdose

Based on the reviews about Nimesil, it was possible to identify the following symptoms of a drug overdose: drowsiness, apathy, pain in the epigastric region, nausea, vomiting. It is also possible the occurrence of gastrointestinal bleeding, acute renal failure, increased blood pressure, respiratory depression, anaphylactoid reactions and coma.

Analogues

The following are drugs with an identical composition, which can replace Nimesil:

• Ameolin (tablets), Aponil (tablets), Affida Fort (granules for suspension), Mesulide (tablets), Nise (tablets, suspension), Negan (tablets), Nimegesic (tablets, suspension), Nimesin (tablets), Nimesulide ( tablets, gel), Nimid (tablets, granules), Nimujet (injection solution), Nimulid (tablets, suspension, injection solution, gel), Nimuspaz (tablets), Pansulide (tablets), Remesulide (tablets), Sulidin (gel), Taro-Sanovel (tablets).

Attention: the use of analogues must be agreed with the attending physician.

Prices

The average price of NIMESIL in pharmacies (Moscow) is 650 rubles.

Storage conditions

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

1. Dasha

   I took only three times one powder. Indeed, the pain stopped. But I have many contraindications for taking Nimesil, I do not risk taking it.

   A neighbor has been taking it constantly for a year, but after taking it she feels great in her legs, works for 3-4 days, and then again pains and she drinks nimesil. But he does not pass tests and does not control, it may turn out that one heals - the other cripples.

2. Olya

   Accidentally “discovered” Nemesil when her knee hurt, she drank only when it was necessary to walk a long distance or some work with a load was coming. Highly!!! satisfied with its action, now it is always in the first-aid kit, although the knee has not been disturbing for three years (there was no more treatment). On the recommendation of the drug, relatives and friends soothe acute toothache and joint pain.

   But I tell everyone that this is only temporary and urgently before consulting a doctor! A neighbor in the country is 75 years old, she takes Nimesil when she cannot sleep at night due to pain in her leg, and even when she goes for mushrooms in the fall. I am also very pleased with his performance. Due to significant contraindications, we do not constantly take the drug, but as a lifesaver, it cannot be replaced!

3. Vitaly

   I tell you how to choose the right medicines: firstly, if the doctor has prescribed something, ask the pharmacy about cheaper analogues. Second, read reviews online. Not always analogues are as effective. Well, you have to try it yourself, if this is some kind of simple medicine without side effects. For example, I picked up an anesthetic and anti-inflammatory Nimesan for back pain. Directly several times cheaper than similar drugs, but it works the same way. What do you think?