Hello, how many days in a row can you drink Nimesil and how many times a day can an adult take it maximum?
Answer from Valentina Alexandrovna Levchenko (doctor)
Hello! As a rule, Nimesil for adults is prescribed in powder form. The drug is packaged in a sachet, one at a time. For maximum effectiveness of the drug, it is necessary to adhere to the recommended regimen for its administration. Ideally, Nimesil therapy is prescribed by a doctor, but I allow the independent use of the drug in case of pain of understandable etiology and the inability to see a doctor.
If we are not talking about a one-time pain relief, say, an attack of toothache, in which you will get to the doctor before this, the effect of the drug will end - there are no special recommendations, except that it is better to drink it after a meal. It is undesirable to take Nimesil again earlier than after 12 hours. If you need to cope with very severe pain, it is allowed to reduce the interval between doses to 8 hours, but not more often.
As for the question of the duration of taking Nimesil, it is not entirely clear to me. This drug is not intended for systemic treatment, its purpose is to help a person take control of pain in order to wait for a doctor's consultation. If the situation is completely hopeless (for example, a severe injury that provokes pain), then I recommend using Nimesil for no longer than a week. Then it is better to check with the doctor than to replace it.
The drug Nimesil is available in dosage form powder for suspension, which is intended for oral administration. It has a light green color, coarse grain and an orange smell. The main active ingredient of the drug is nimesulide, its content in 1 sachet of powder is 100 mg. The drug also contains additional compounds, which include:
- Sucrose.
- Orange flavor.
- Ketomacrogol.
- Anhydrous citric acid.
- Maltodextrin.
Nimesil powder is packaged in aluminum foil bags of 2 g each. A carton pack contains 9, 15 or 30 bags.
Action
The active ingredient of Nimesil powder refers to selective (selective) antagonists of the COX-2 enzyme (cyclooxygenase-2), which suppress its activity. COX-2 catalyzes the conversion of arachidonic acid into the main mediators of the inflammatory reaction, prostaglandins, which are synthesized by the cells of the immune system in response to the development of the pathological process. A decrease in the concentration of prostaglandins leads to a decrease in the manifestations of the inflammatory reaction, which include pain (prostaglandins irritate sensitive nerve endings), tissue edema (the exit of the liquid part of the blood from the vascular bed into the intercellular substance of the tissues), as well as stagnation of blood in the vessels of the microvasculature.
After taking a suspension prepared from Nimesil powder, the active ingredient is quickly and completely absorbed into the blood. It is evenly distributed in tissues, where it has therapeutic effects. Nimesulide is metabolized primarily in the liver to form inactive products that are excreted in the urine. The half-life (the time of elimination from the body of half of the entire dose of the drug) for nimesulide is about 6 hours.
Indications
Taking a suspension prepared from Nimesil powder is indicated to reduce the severity of the inflammatory reaction and pain in certain diseases, which include:
- Pain in the back, lower back, which is of inflammatory origin.
- Various pathological processes in the structures of the musculoskeletal system, which include trauma, inflammation of the ligaments (tendonitis), sprains, dislocations and subluxations of various joints.
- Toothache.
- Headache of various origins, including migraine of moderate severity.
- Painful menstruation in women (dysalgomenorrhea).
The drug is intended only for symptomatic and pathogenetic treatment of pain and inflammatory syndrome. It does not affect the main cause of the development of the pathological process.
Contraindications
Nimesil powder should not be taken if a person has certain pathological processes or physiological conditions, which include:
- A peptic ulcer characterized by a violation of the integrity of the mucous membrane of the stomach or duodenum. This is due to the fact that the drug Nimesil partially reduces the level of prostaglandins, which are responsible for protecting the mucous membrane of the upper sections. gastrointestinal tract from aggressive factors (hydrochloric acid of gastric juice).
- Past gastrointestinal bleeding, including on the background of peptic ulcer.
- Non-infectious inflammatory chronic bowel diseases in the acute stage (ulcerative colitis).
- Feverish conditions, accompanied by an increase in body temperature, in particular in acute respiratory viral pathology, bacterial infections.
- The presence of allergic diseases, including a combination of polynosis, bronchial asthma, as well as intolerance to acetylsalicylic acid, which is non-steroidal anti-inflammatory drugs.
- Hypersensitivity (hypersensitization) of the body to acetylsalicylic acid, including those suffered in the past and accompanied by bronchospasm (allergic bronchitis), inflammation of the nasal mucosa, urticaria.
- Recovery period after coronary artery bypass surgery.
- A history of diseases accompanied by increased bleeding, hemorrhagic stroke of the brain.
- Severe disorders, accompanied by a violation of blood coagulation (decrease in the functional activity of the hemostasis system).
- A pronounced decrease in the functional activity of the heart (severe heart failure).
- The combined use of drugs that have a negative effect on the state of the liver (hepatotoxic medicines).
- Severe renal or hepatic failure.
- Chronic alcoholism or drug addiction.
- Pregnancy or the period of breastfeeding (lactation) in a woman.
- The patient's age is less than 12 years.
- Individual intolerance to any of the components of the drug.
With caution, Nimesil powder is used for concomitant type 2 diabetes mellitus, high blood pressure (arterial hypertension), coronary heart disease, peripheral arterial pathology, smoking, concomitant use of drugs that reduce blood clotting (non-steroidal anti-inflammatory drugs, clopidogrel, heparin and its analogues) , as well as hormonal anti-inflammatory drugs (glucocorticosteroids).
How to dilute Nimesil powder?
Powder Nimesil is intended for the preparation of a suspension that is taken orally. One sachet is dissolved in 1 glass of water with a volume of 100 ml. The prepared suspension should be used immediately, it is not subject to storage. The average therapeutic dosage is 100 mg nimesulide (1 sachet) 2 times a day. The maximum duration of the course of therapy with Nimesil powder should not exceed 15 days. Dosage adjustment for adolescents over 12 years of age, the elderly, and patients with concomitant non-severe renal insufficiency is usually not required.
Side effects
Against the background of taking a suspension prepared from Nimesil powder, it is possible to develop negative reactions from various organs and systems:
- Digestive system - nausea, periodic vomiting, diarrhea (diarrhea). Rarely develops abdominal pain, constipation, bloating (flatulence), signs of bleeding from the structures of the gastrointestinal tract in the form of tarry dark stools.
- Cardiovascular system - increased blood pressure, heart rate (tachycardia), sensation of hot flashes.
- Nervous system - dizziness, rarely develops a headache, nervousness of a person, nightmares, a feeling of fear.
- Liver and biliary tract - inflammation of the liver (hepatitis), which very rarely can have a fulminant form, the development of jaundice, an increase in the activity of liver enzymes (ALT, AST) in the blood, indicating damage to liver cells (hepatocytes).
- Respiratory system - shortness of breath, exacerbation of bronchial asthma is very rare.
- Urinary system - Rarely, blood may appear in the urine (hematuria), and urination itself becomes painful (dysuria).
- Sense organs - blurred vision.
- The system of blood and red bone marrow - anemia (anemia), an increase in the number of eosinophils (eosinophilia), a decrease in the number of platelets (thrombocytopenia) in the blood.
- Allergic reactions - itching, skin rash, increased sweating, less likely to develop urticaria (skin changes resembling a nettle burn), anaphylactoid reactions with severe peripheral tissue edema (Quincke's edema) or a critical decrease in systemic blood pressure with multiple organ failure (anaphylactic shock) ).
The appearance of any of the signs of the development of side effects after the start of taking a suspension prepared from Nimesil powder is the basis for discontinuing the drug.
Peculiarities
Before you start taking a suspension prepared from Nimesil powder, it is important to carefully read the instructions for the medication. There are several features of the correct use of the drug, which include:
- The active substance of the drug may interact with drugs of other pharmacological groups, so when using them, you should consult a medical specialist.
- The likelihood of developing negative reactions is reduced when using the drug in a minimum course at an effective minimum dosage.
- Moderate kidney failure requires a reduction in the dosage of Nimesil powder.
- An auxiliary component of the drug is sucrose, which must be taken into account when prescribing to patients with concomitant diabetes.
- Do not take Nimesil powder simultaneously with other non-steroidal anti-inflammatory drugs.
- The effect of the drug on the functional activity of the central nervous system has not been reliably studied, therefore, against the background of the use of Nimesil powder, it is recommended to be careful when engaging in activities associated with the need for a sufficient reaction rate.
In the pharmacy network, Nimesil powder is dispensed by prescription. It is not recommended to take the drug on its own without appropriate prescriptions.
Overdose
A significant excess of the recommended therapeutic dosage of Nimesil powder is accompanied by the appearance of nausea, accompanied by periodic vomiting, apathy, drowsiness, abdominal pain, more pronounced in the stomach (upper abdomen or epigastrium), gastrointestinal bleeding. Overdose treatment is carried out in a medical institution. It is symptomatic, as there is currently no specific antidote. The stomach and intestines are washed, intestinal sorbents are prescribed (Activated charcoal, Smecta, Enterosgel).
Analogues
In terms of composition and therapeutic effects for Nimesil, the drugs Nimesulide, Nise, Nemulx are similar.
Storage
The shelf life of Nimesil powder is 2 years. Suspension prepared from powder is not subject to storage. The drug should be stored in a dark, dry place inaccessible to children at an air temperature not higher than + 25 ° C.
Nimesil price
The average cost of a package of Nimesil powder containing 30 sachets in Moscow pharmacies varies within the limits of rubles.
Nimesil
Description current as of 10/13/2015
- Latin name: Nimesil
- ATX code: M01AX17
- Active ingredient: Nimesulide (Nimesulide)
- Manufacturer: Laboratorios MENARINI (Spain)
Composition of Nimesil
The composition of the drug includes nimesulide in the amount of 100 mg per 1 sachet.
Additional substances: sucrose, ketomacrogol, citric acid, orange flavor, maltodextrin.
Release form
The medicine Nimesil is a granule for the manufacture of oral suspension in the form of a light yellow powder with an orange smell.
2 grams of Nimesil in a paper bag; 9, 30 or 15 sachets in a carton.
pharmachologic effect
Antipyretic, anti-inflammatory, analgesic effect.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Anti-inflammatory non-steroidal drug from the group of sulfonamides. It has anti-inflammatory, antipyretic and analgesic effects. Wikipedia indicates that the active substance acts as a blocker of type 2 cyclooxygenase, which is responsible for the biosynthesis of prostaglandins.
Pharmacokinetics
After administration, it is well absorbed in the intestine, reaching the highest concentration in the blood after 2-3 hours. Reaction with plasma proteins is 97.5%. The half-life is 4-5 hours. Quickly penetrates through histohematic barriers.
It is transformed in the liver under the action of cytochrome P450. The main active metabolite is hydroxynimesulide, which is excreted in the bile in a glucuronized form. Excreted from the body, mainly by the kidneys (about half of the accepted dose).
Indications for the use of Nimesil powder
The drug serves for symptomatic therapy, relief of inflammation and pain at the time of use.
Indications for Nimesil's use:
- symptomatic therapy of pain syndrome on the background of osteoarthritis;
- relief of acute pain (pain in the lower back and back; pain syndrome in injuries, tendonitis, bursitis, sprains and dislocations; toothache);
- algomenorrhea.
Contraindications for Nimesil
Contraindications for use:
- hepatotoxic reactions caused by the active substance in history;
- bronchospasm, urticaria, rhinitis associated with the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs in history;
- co-administration of drugs with potential hepatotoxicity;
- condition after coronary artery bypass grafting;
- inflammatory bowel disease (ulcerative colitis, Crohn's disease) in the acute stage;
- an increase in body temperature in diseases of an infectious and inflammatory nature;
- exacerbation of peptic ulcer, a history of ulcer, perforation or bleeding in the organs of the digestive tract;
- a combination of bronchial asthma, nasal polyposis and intolerance to non-steroidal anti-inflammatory drugs;
- bleeding of cerebrovascular or other localizations; diseases accompanied by pathological bleeding;
- decompensated heart failure;
- severe disorders of blood coagulation;
- decompensated renal failure, hyperkalemia;
- liver disease;
- liver failure;
- alcoholism, drug addiction;
- pregnancy or lactation;
- age under 12;
- hypersensitivity to the components of the drug.
The summary recommends using Nimesil with caution if severe forms of type 2 diabetes mellitus or arterial hypertension are present; ischemic disease, heart failure, dyslipidemia, cerebrovascular disease, peripheral arterial disease, elderly age; peptic ulcer in the past, infections associated with Helicobacter pylori; prolonged prior use of non-steroidal anti-inflammatory drugs; decompensated somatic diseases; when smoking and concomitant treatment with anticoagulants, oral glucocorticosteroids, antiplatelet agents, selective serotonin reuptake blockers.
Side effects
From a toothache, from a headache, with a cold, with menstruation, Nimesil is often used in medical practice, which can cause the following side effects:
Application instruction of Nimesil (Way and dosage)
Instructions on how to breed Nimesil
The drug in powder (granules) is placed in a glass and diluted with approximately 100 ml of water. The finished solution is not subject to storage, it must be taken as soon as possible. There is a common question: “in what water should the powder be dissolved?”. The instruction recommends dissolving the medicine in warm, boiled water.
Powder Nimesil, instructions for use
The medicine (after preparation) is taken orally, twice a day, 1 sachet, after meals. The maximum duration of treatment is two weeks.
To reduce the risk of side effects, it is recommended to use the lowest effective dosage for the shortest possible time.
Instructions for use Nimesil for children
Nimesil (as well as tablets or ointment based on nimesulide) is not allowed to be used for treatment in children under 12 years of age. Children are recommended to take standard doses.
Instructions on how to take granules for people with a kidney disorder
There is no need to change the dose in individuals with mild to moderate renal insufficiency.
How to take Nimesil powder for elderly patients
In the treatment of elderly patients, the need to change the daily dosage is determined by the doctor, taking into account the possibility of interaction with other drugs taken.
Overdose
Signs of overdose: vomiting, drowsiness, apathy, nausea, epigastric pain. The development of gastrointestinal bleeding is not excluded. In very rare cases, there is a possibility of an increase in blood pressure, the appearance of acute kidney failure, respiratory depression, anaphylactoid reactions, coma.
Treatment of overdose is symptomatic. There is no selective antidote. If no more than 4 hours have passed since the overdose, it is necessary to wash the stomach and ensure the intake of enterosorbens, for which they use Activated carbon or an osmotic laxative. Shows control over the work of the kidneys and liver.
Interaction
With simultaneous use with glucocorticosteroids, the risk of ulcers or bleeding from the stomach and intestines increases.
When used with antiplatelet agents and selective serotonin reuptake inhibitors, the likelihood of bleeding from the stomach or intestines is also increased.
Non-steroidal anti-inflammatory drugs can enhance the effects of anticoagulants, so this combination is not recommended for people with severe coagulation disorders. If this combination still can not be avoided, it is necessary to carefully monitor the parameters of blood clotting.
Anti-inflammatory non-steroidal drugs can weaken the effects of diuretics.
Nimesulide is able to temporarily reduce the evacuation of sodium and potassium under the influence of Furosemide and thereby weaken the diuretic effect of the latter. It must also be remembered that such co-administration of drugs requires caution in individuals with impaired renal and cardiac function.
Anti-inflammatory non-steroidal agents may weaken the effect of antihypertensive agents. In persons with compensated renal insufficiency, while prescribing ACE blockers, angiotensin receptor antagonists of the second type, or agents that suppress cyclooxygenase, progression of deterioration in kidney function and the development of reversible acute renal failure is possible.
Anti-inflammatory non-steroidal drugs reduce the clearance of lithium, which causes an increase in the level of the latter in the blood.
When prescribing Nimesil less than a day before or after the use of Methotrexate, care must be taken, since in such cases the content of Methotrexate in the blood and its toxic effects may increase.
Nimesulide is able to stimulate the nephrotoxicity of cyclosporins.
Terms of sale
Storage conditions
Store in a dry, dark place at room temperature. Keep away from children.
Best before date
special instructions
Side effects can be minimized by using the lowest effective dosage of the drug for the shortest possible course.
The medicine in Nimesil powder should be used with caution in individuals with a history of gastrointestinal diseases, since an exacerbation of these diseases is not excluded.
Since the drug is partially evacuated by the kidneys, its dosage for people with impaired renal function should be reduced depending on the amount of urination.
When the first symptoms of liver damage appear (itching, yellowing of the skin, nausea, abdominal pain, vomiting, dark urine, an increase in the content of "liver" transaminases), it is necessary to stop taking the medication and consult a doctor.
If any signs of visual impairment appear during drug therapy, the patient should be examined by an ophthalmologist.
Nimesil is able to provoke fluid retention in the body, so people with high blood pressure and heart disease should use the drug with extreme caution.
If symptoms of an acute respiratory infection of a viral nature occur during drug therapy, Nimesil should be stopped.
Nimesil should not be used simultaneously with other anti-inflammatory nonsteroidal drugs.
Nimesulide is able to change the characteristics of platelets, so care must be taken when using the drug in patients with hemorrhagic diathesis. It is worth remembering that the drug does not replace the preventive effect of acetylsalicylic acid in diseases of the circulatory system.
Nimesil's analogs
Nise or Nimesil - which is better?
Nise and Nimesil are analogues. The main difference between the drugs is that the first is available in the form of a gel for topical use and tablets, and the cost of Nise is an order of magnitude lower. The choice should be made based on the recommendations of the doctor, the type of indication and economic considerations.
Nimesil for children
Nimesil (as well as tablets or ointment based on nimesulide) is not allowed to be used for treatment in children under 12 years of age. The instruction for the drug for children indicates that the method of using Nimesil (how to use and how to dilute the powder) in the rest age groups is not different. How to use the powder, how to dilute Nimesil in powder, and how to drink Nimesil in powder, is described in the section "Instructions for using Nimesil (Method and dosage)"
Can Nimesil be given to children at a temperature?
This medicine is not the drug of choice for lowering body temperature, although it has a mild antipyretic effect. Nimesil should be used only for the purpose of stopping mild and moderately mild pain.
Alcohol compatibility
Nimesil and alcohol are incompatible, since both substances are hepatotoxic. Their simultaneous use can lead to severe disorders of the liver and irreversible consequences, especially against the background of already present diseases of the hepatobiliary system.
Nimesil during pregnancy and lactation
The use of the drug during pregnancy or breastfeeding is strictly prohibited, since nimesulide and other anti-inflammatory non-steroidal drugs can adversely affect the course of pregnancy and the development of the child.
Reviews about Nimesil
With toothache and other types of pain (associated with injuries, algomenorrhea), Nimesil powder is widely used. Reviews of its use among patients are positive and there is little evidence of the development of undesirable effects.
Reviews of doctors about Nimesil also characterize the drug well as a remedy that effectively relieves pain of a traumatic nature, and pain localized in the musculoskeletal system. However, it is worth remembering that in a number of countries nimesulide preparations are completely prohibited due to increased hepatotoxic ability.
Nimesil is an antibiotic or not?
A common question among patients. Nimesil is not an antibiotic and does not have an antibacterial effect. Its main effects: antipyretic, analgesic, anti-inflammatory.
Nimesil price, where to buy
The price of Nimesil powder (9 sachets) in Russia reaches 615 rubles. For comparison, the price of 1 sachet of Nimesil is a ruble.
The average price in Ukraine of drug No. 1 is about 9 hryvnias, and the price of a package, including 30 sachets, fluctuates within hryvnias.
How much does an analogue of Nimesil Nise cost?
The cost of this drug in Russia in the form of a 100 mg No. 20 tablet is rubles, and in the ointment of the same name 1% 20 grams will cost rubles.
Nimesil - instructions for use, reviews, analogs and forms of release (powder or granules for the preparation of a suspension of 100 mg) drugs for the treatment and relief of pain in adults, children and pregnancy. Composition and interaction with alcohol
In this article, you can read the instructions for using the drug Nimesil. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Nimesil in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Nimesil in the presence of existing structural analogues. Use for the treatment and relief of pain in various diseases in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.
Nimesil is a non-steroidal anti-inflammatory drug from the sulfonamide class. It has anti-inflammatory, analgesic and antipyretic effects. Nimesulide acts as an inhibitor of the cyclooxygenase enzyme responsible for the synthesis of prostaglandins and inhibits mainly cyclooxygenase-2.
Nimesulide + excipients.
After oral administration, the drug is well absorbed from the gastrointestinal tract. Easily penetrates through histohematic barriers. Nimesulide (the active substance of the drug Nimesil) is excreted from the body, mainly by the kidneys (about 50% of the dose taken). With repeated administration of the drug, cumulation is not observed.
- treatment of acute pain (pain in the back, lower back; pain in the musculoskeletal system, including injuries, sprains and dislocations of the joints, tendonitis, bursitis; toothache);
- symptomatic treatment of osteoarthritis with pain syndrome;
- algomenorrhea.
The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use.
Powder or granules for oral suspension 100 mg.
Forms in the form of tablets at the time of the description of the drug in the directory did not exist.
Instructions for use and regimen
Nimesil is taken orally, 1 sachet (100 mg of nimesulide) 2 times a day. The drug is recommended to be taken after meals. The contents of the sachet are poured into a glass and dissolved in about 100 ml of water. The prepared solution cannot be stored.
Nimesil is used only for the treatment of patients older than 12 years.
Adolescents (aged 12 to 18 years): based on the pharmacokinetic profile and pharmacodynamic characteristics of nimesulide, there is no need for dose adjustment in adolescents.
Elderly patients: in the treatment of elderly patients, the need to adjust the daily dose is determined by the doctor based on the possibility of interaction with other drugs.
The maximum duration of treatment with nimesulide is 15 days.
To reduce the risk of unwanted side effects, the minimum effective dose should be used for the shortest possible course.
- anemia;
- eosinophilia;
- hemorrhagic syndrome;
- thrombocytopenia;
- pancytopenia;
- thrombocytopenic purpura;
- rash;
- increased sweating;
- dermatitis;
- anaphylactoid reactions;
- hives;
- angioedema;
- dizziness;
- nervousness;
- headache;
- drowsiness;
- blurry vision;
- arterial hypertension;
- tachycardia;
- dyspnea;
- exacerbation of bronchial asthma;
- bronchospasm;
- diarrhea, constipation;
- nausea, vomiting;
- stomach ache;
- dyspepsia;
- stomatitis;
- tarry stool;
- gastrointestinal bleeding;
- ulcer and / or perforation of the stomach or duodenum;
- jaundice;
- hematuria (blood in the urine);
- urinary retention;
- hyperkalemia.
- history of hyperergic reactions, for example, bronchospasm, rhinitis, urticaria, associated with the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs), incl. nimesulide;
- hepatotoxic reactions to nimesulide in history;
- concomitant (simultaneous) use of drugs with potential hepatotoxicity, for example, paracetamol or other analgesic or non-steroidal anti-inflammatory drugs;
- inflammatory bowel disease (Crohn's disease, ulcerative colitis) in the acute phase;
- the period after coronary artery bypass grafting;
- fever in infectious and inflammatory diseases;
- complete or partial combination of bronchial asthma, recurrent polyposis of the nose or paranasal sinuses with intolerance to acetylsalicylic acid and other NSAIDs (including history);
- peptic ulcer of the stomach and duodenum in the acute phase, the presence of an ulcer in history, perforation or bleeding in the gastrointestinal tract;
- a history of cerebrovascular bleeding or other bleeding, as well as diseases accompanied by bleeding;
- severe blood clotting disorders;
- severe heart failure;
- severe renal failure (CK< 30 мл/мин), подтвержденная гиперкалиемия;
- liver failure or any active liver disease;
- children's age up to 12 years;
- pregnancy and breastfeeding period;
- alcoholism (simultaneous intake with alcohol is prohibited due to the risk of bleeding from the gastrointestinal tract), drug addiction;
- hypersensitivity to the components of the drug.
Use during pregnancy and lactation
Like other drugs of the NSAID class that inhibit the synthesis of prostaglandins, Nimesil can adversely affect the course of pregnancy and / or the development of the embryo and can lead to premature closure of the arterial duct, hypertension in the pulmonary artery system, impaired renal function, which can turn into renal failure. with oligodyramnia, to an increased risk of bleeding, a decrease in uterine contractility, the occurrence of peripheral edema. In this regard, the drug is contraindicated during pregnancy and during breastfeeding.
Unwanted side effects can be minimized by using the lowest effective dose of the drug for the shortest possible course.
Nimesil should be used with caution in patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease), since exacerbation of these diseases is possible.
The risk of gastrointestinal bleeding, ulceration or perforation of the ulcer increases with increasing dose of NSAIDs in patients with a history of ulcers, especially complicated by bleeding or perforation, as well as in elderly patients, so treatment should be started with the lowest possible dose. Patients receiving drugs that reduce blood clotting or inhibit platelet aggregation also increase the risk of gastrointestinal bleeding. In the event of gastrointestinal bleeding or ulcers in patients taking Nimesil, treatment with the drug should be discontinued.
Since Nimesil is partially excreted by the kidneys, its dosage for patients with impaired renal function should be reduced, depending on the level of urination.
There is evidence of the occurrence of rare cases of reactions from the liver. If signs of liver damage appear (skin itching, yellowing of the skin, nausea, vomiting, abdominal pain, darkening of urine, increased activity of "liver" transaminases), you should stop taking the drug and consult your doctor.
Despite the rarity of visual impairment in patients taking nimesulide simultaneously with other NSAIDs, treatment should be stopped immediately. If any visual disturbance occurs, the patient should be examined by an ophthalmologist.
The drug can cause fluid retention in the tissues, so patients with high blood pressure and cardiac disorders should use Nimesil with extreme caution.
In patients with renal or heart failure, Nimesil should be used with caution, as renal function may deteriorate. If the condition worsens, treatment with Nimesil should be discontinued.
Clinical studies and epidemiological data suggest that NSAIDs, especially at high doses and with long-term use, may lead to a small risk of myocardial infarction or stroke. There are not enough data to exclude the risk of such events when using nimesulide.
The composition of the drug includes sucrose, this should be taken into account for patients with diabetes mellitus (0.15-0.18 XE per 100 mg of the drug) and people on a low-calorie diet. Nimesil is not recommended for patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltose deficiency.
If there are signs of a "cold" or an acute respiratory viral infection during treatment with Nimesil, the drug should be discontinued.
Nimesil should not be used simultaneously with other NSAIDs.
Nimesulide can change the properties of platelets, so care must be taken when using the drug in people with hemorrhagic diathesis, but the drug does not replace the preventive effect of acetylsalicylic acid in cardiovascular diseases.
Elderly patients are particularly susceptible to adverse reactions to NSAIDs, including life-threatening gastrointestinal bleeding and perforations, deterioration of kidney, liver and heart function. When taking the drug Nimesil for this category of patients, proper clinical monitoring is necessary.
Like other NSAIDs that inhibit prostaglandin synthesis, nimesulide may adversely affect pregnancy and/or fetal development and may lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired renal function, which may progress to renal failure. with oligodyramnia, to an increased risk of bleeding, a decrease in uterine contractility, the occurrence of peripheral edema. In this regard, nimesulide is contraindicated during pregnancy and lactation. The use of the drug Nimesil can adversely affect female fertility and is not recommended for women planning a pregnancy. When planning pregnancy, consultation with your doctor is necessary.
Simultaneous administration of the drug Nimesil with alcohol is prohibited due to the risk of bleeding from the gastrointestinal tract.
There is evidence of the occurrence in rare cases of skin reactions (such as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) to nimesulide as well as to other NSAIDs. At the first sign of a skin rash, mucosal lesions or other signs of an allergic reaction, Nimesil should be discontinued.
The effect of the drug on the ability to drive vehicles and control mechanisms
The effect of Nimesil on the ability to drive vehicles and control mechanisms has not been studied, therefore, during the period of treatment with Nimesil, care should be taken when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
When combined with glucocorticosteroids, the risk of gastrointestinal ulcers or bleeding increases.
When combined with antiplatelet agents and selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, the risk of gastrointestinal bleeding increases.
NSAIDs may increase the effect of anticoagulants such as warfarin. Due to the increased risk of bleeding, this combination is not recommended and contraindicated in patients with severe coagulation disorders. If combination therapy still cannot be avoided, careful monitoring of blood coagulation parameters should be carried out.
NSAIDs can weaken the effect of diuretics.
In healthy volunteers, nimesulide temporarily reduces sodium excretion under the action of furosemide, to a lesser extent, potassium excretion, and reduces the actual diuretic effect.
Co-administration of Nimesil and furosemide leads to a decrease (approximately 20%) in the area under the concentration-time curve (AUC) and a decrease in the cumulative excretion of furosemide without changing the renal clearance of furosemide.
The co-administration of furosemide and nimesulide requires caution in patients with impaired renal and cardiac function.
ACE inhibitors and angiotensin II receptor antagonists
NSAIDs may reduce the effect of antihypertensive drugs. In patients with mild to moderate renal insufficiency (CKml / min), when co-administered with ACE inhibitors, angiotensin 2 receptor antagonists or substances that suppress the cyclooxygenase system (NSAIDs, antiplatelet agents), further deterioration of renal function and the occurrence of acute renal failure, which, as the rule is reversible. These interactions should be considered in patients taking Nimesil in combination with ACE inhibitors or angiotensin 2 receptor antagonists. Therefore, the combined use of these drugs should be prescribed with caution, especially for elderly patients. Patients should be adequately hydrated and renal function should be closely monitored after initiation of concomitant therapy.
Pharmacokinetic interactions with other drugs
There is evidence that NSAIDs reduce the clearance of lithium, which leads to an increase in the concentration of lithium in the blood plasma and its toxicity. When prescribing nimesulide to patients receiving lithium therapy, regular monitoring of plasma lithium concentrations should be carried out.
Clinically significant interactions with glibenclamide, theophylline, digoxin, cimetidine and antacids (for example, a combination of aluminum and magnesium hydroxides) were not observed.
When prescribing nimesulide less than 24 hours before or after taking methotrexate, caution is required, since in such cases the plasma level of methotrexate and, accordingly, the toxic effects of this drug may increase.
In connection with the action on renal prostaglandins, prostaglandin synthetase inhibitors, such as nimesulide, may increase the nephrotoxicity of cyclosporins.
Interaction of other drugs with nimesulide
Studies have shown that nimesulide is displaced from the binding sites by tolbutamide, salicylic acid and valproic acid. Despite the fact that these interactions were determined in blood plasma, these effects were not observed during the clinical use of the drug.
Analogues of the drug Nimesil
Structural analogs of the active substance.
Modern pharmacological firms are full of a variety of painkillers and antipyretics. Such drugs are probably in every home first aid kit. They help the patient quickly get rid of pain and fever, which can appear suddenly. Practice shows that one of the most effective and sought-after medicines is Nimesil. Instructions, reviews and description of the drug will be given for your attention in today's article. You will also find out how you can replace this tool.
What is Nimesil?
"Nimesil" is a powder that is produced by a German pharmacological company. It contains the medicinal substance nimesulide. The drug is packaged in sachets, each containing 100 mg of the main component and 2 grams in total. The manufacturer here uses additional components: sucrose, citric acid, ketomacrogol, maltodextrin and orange flavor.
"Nimesil" - has analgesic and antipyretic effects. It is also able to eliminate the inflammatory process that occurs in the body. The drug is included in the list of non-steroidal anti-inflammatory drugs that are sold without a prescription. The cost of 30 bags is about 700-800 rubles. Some pharmacies sell sachets by the piece.
The manufacturer about the drug
The annotation says that Nimesil is a great way to get rid of the pain caused by different reasons. The medication is used when:
- I have a toothache;
- pain occurs after surgery or minimally invasive interventions;
- the patient is diagnosed with arthritis or other pathologies of the musculoskeletal system, accompanied by pain.
The medicine effectively eliminates fever, which may occur with infectious diseases or for other reasons. The use of Nimesil powder is a way to eliminate the inflammatory process occurring in the joints and soft tissues. Also, the medication is used for vascular, gynecological and urological pathologies.
Contraindications for use
Before using the drug "Nimesil", instructions for use (reviews say this) should be carefully read. Particular attention should be paid to the point where contraindications are stipulated. If you have the same at least one, then the use of the medication should be abandoned. Powder "Nimesil" is contraindicated:
- with high sensitivity of the patient's body to the active substance or other components;
- ulcerative lesions of the intestine or stomach;
- bleeding in the digestive tract;
- pregnancy, as it can have a negative effect on its course and the formation of the fetus;
- breastfeeding due to unhindered penetration into milk;
- increased pressure;
- kidney failure.
It is forbidden to use the medicine in pediatrics, unless otherwise specified by the doctor individually.
"Nimesil": application
Reviews about the drug say that it is quite pleasant to take it. The drug is taken orally in liquid form, it has a sweet taste and does not cause disgust. The instruction recommends using the medicine only after eating, since the active substance can adversely affect the gastric mucosa.
A single dose of the drug is 100 mg of nimesulide, which is equal to one sachet. In case of urgent need, the portion of the medicine can be doubled. Daily rate the drug is 200 mg, it should not be exceeded alone.
Before taking it is necessary to prepare the medication. How to breed "Nimesil", the instruction tells in detail. To do this, you will need 250 ml of clean drinking water. Pour the powder into a container and mix thoroughly. Drink the solution when the granules are completely dissolved. Do not store finished medicine. Dilute a new dose before each dose.
Consequences of therapy
It is expected that the drug will have a positive effect on the human body in the form of lowering fever and eliminating pain. The drug blocks the synthesis of prostaglandins in the focus of inflammation. The tool works for at least 6 hours. But for some people, the medication works differently. It causes side reactions, which can be expressed as follows:
- disorders of the digestive system (heartburn, abdominal pain, diarrhea or constipation, nausea);
- effects on the central nervous system (dizziness, headache, fatigue and drowsiness);
- allergies (skin rash and itching,;
- violations of the outflow of fluid (edema, malfunction of the kidneys).
If one or more of the described symptoms appear, you should immediately stop treatment and seek help from a medical institution.
Additional information about the medication
The manufacturer tells a lot of important information about the drug, which must be taken into account if you are going to take the claimed remedy:
- "Nimesil" for children younger age not assigned under any circumstances. Adolescents can be treated, but only if prescribed by a doctor, taking into account the benefits and risks. In each situation, an individual dose of the drug is selected.
- Patients with a history of gastrointestinal diseases should use the medicine with extreme caution, as pathologies may worsen. To reduce the risk, it is necessary to take the minimum dose of the drug in a short course.
- The drug contains sucrose. This should be noted in patients with diabetes, fructose intolerance, or those on a low-calorie diet.
- Nimesil should not be combined with other drugs of the NSAID group.
- Medicines that reduce blood clotting, taken together with Nimesil, enhance their effect.
Analogues
You can replace the drug with similar means based on nimesulide. You can choose from the following medications:
- "Nimulid" - a syrup approved for use in children from the age of one;
- "Nise" - tablets containing 100 mg of active ingredient in each pill;
- "Nimesulide" - granules for the preparation of a solution;
- "Nemulex" - granules acceptable for use in children from 12 years old;
- "Aponil" - tablets of 100 mg;
- "Nimika" - dispersible tablets.
If for some reason Nimesil is not suitable for you, you can choose tablets based on another active ingredient. Safer means are drugs based on ibuprofen and paracetamol. Trade names of such drugs: "Kalpol", "Panadol", "Nurofen", "Ibuklin" and so on. You can buy them without a prescription in almost every pharmacy chain. You can replace the drug "Nimesil" with the help of "Diklovit", "Ketorol", "Ketonal" and many others. If the claimed medicine does not suit you, then contact a specialist to select an alternative remedy.
Pharmacodynamics. Nimesulide (4-nitro-2-phenoxymethanosulfonanilide) - NSAIDs of the methanesulfonanilide group, has anti-inflammatory, analgesic and antipyretic effects. Therapeutic effect nimesulide is due to the fact that it affects the metabolism of arachidonic acid and reduces the biosynthesis of prostaglandins by inhibiting COX. Due to the selective action on COX-2, the synthesis of prostaglandins with a cytoprotective effect in the gastric mucosa is not disturbed, and the risk of side effects is reduced. In addition, nimesulide reduces the formation of superoxide anions by neutrophilic granulocytes and inhibits the formation free radicals formed during inflammation.
Pharmacokinetics. Well absorbed when taken orally, reaching Cmax in plasma after 2-3 hours. Up to 97.5% of nimesulide binds to plasma proteins.
Nimesulide is actively metabolized in the liver with the participation of CYP 2C9, an isoenzyme of cytochrome P450. The main metabolite is a parahydroxy derivative, which also has pharmacological activity. T1 / 2 - 3.2-6 hours. Nimesulide is excreted from the body with urine - about 50% of the dose taken. About 29% of the dose taken is excreted in the feces in a metabolized form, and only 1-3% is excreted from the body in an unchanged state. The pharmacokinetic profile in the elderly does not change. With prolonged use does not accumulate in the body.
Indications for the use of the drug Nimesil
Acute pain syndrome. Symptomatic treatment of osteoarthritis with pain syndrome. primary dysmenorrhea.
Application of the drug Nimesil
Nimesil is prescribed after a thorough assessment of the benefit/risk ratio. Use the lowest effective dose for the shortest amount of time to reduce side effects. The maximum duration of treatment with Nimesil is 15 days.
Adults and the elderly: 1 sachet of 100 mg 2 times a day (daily dose - 200 mg). Children over the age of 12: dose adjustment is not required.
Patients with impaired renal function: for patients with mild or moderate renal insufficiency (creatinine clearance - 30-80 ml / min), dose adjustment is not required.
The contents of portioned sachets are poured into a glass, dissolved with water and taken orally after a meal.
Contraindications to the use of the drug Nimesil
Hypersensitivity to nimesulide or to any component of the drug. Hyperergic reactions in history (bronchospasm, rhinitis, urticaria) in connection with the use of acetylsalicylic acid or other NSAIDs. History of hepatotoxic reaction to nimesulide. Peptic ulcer of the stomach or duodenum in the acute phase, recurrent peptic ulcers or gastrointestinal bleeding, cerebrovascular bleeding or other bleeding conditions. Significant bleeding disorder. Severe heart failure. Severe renal failure. Liver failure. Children under the age of 12. In the III trimester of pregnancy and the period of breastfeeding. Fever and flu-like symptoms, suspicion of acute surgical pathology. Do not use simultaneously with other drugs that may cause hepatotoxic reactions. Alcoholism and drug addiction.
Side effects of the drug Nimesil
The frequency of side effects is classified as follows: very often (≤1/10); often (1/100 and ≤1/10); sometimes (1/1000 and ≤1/100); rarely (1/10,000 and ≤1/1000); very rarely (≤1/10,000), including special cases.
- Rare Anemia, eosinophilia.
- Very rarely Thrombocytopenia, pancytopenia, purpura.
From the immune system:
- Rare Hypersensitivity
- Very rare Anaphylaxis
Disorders of metabolism and metabolism:
- Rare Hyperkalemia
Mental disorders:
- Rare Fear, nervousness, nightmares
From the nervous system:
- Sometimes dizziness
- Very rare Headache, drowsiness, encephalopathy (Reye's syndrome)
- Rare Blurred vision
- Very rare Visual impairment
From the organ of hearing and balance:
- Very rare Dizziness
From the side of the cardiovascular system:
- Sometimes Hypertension
- Rare Tachycardia, hemorrhage, BP lability, hot flashes
From the respiratory system:
- Sometimes shortness of breath
- Very rare asthma, bronchospasm
From the gastrointestinal tract:
- Common Diarrhea, nausea, vomiting
- Sometimes Constipation, flatulence, gastritis
- Very rare Abdominal pain, dyspepsia, stomatitis, black discoloration of stool (melena), gastrointestinal bleeding, ulcer, perforating gastric and duodenal ulcer
From the liver and biliary system:
- Very rare Hepatitis, fulminant hepatitis (including fatal cases), jaundice, cholestasis
From the skin and appendages:
- Sometimes Itching, skin rash, excessive sweating
- Rare Erythema, dermatitis
- Very rare Urticaria, angioedema, facial edema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis
- Rarely Dysuria, hematuria, urinary retention.
- Very rare Renal failure, oliguria, interstitial nephritis
General violations:
- Sometimes swelling
- Rare Weakness, asthenia
- Very rare Hypothermia
Laboratory data:
- Often Increased levels of hepatic transaminases.
Special instructions for the use of the drug Nimesil
The risk of side effects can be reduced if nimesulide, if possible, is used for a minimum period of time. Treatment should be stopped if there is no positive clinical effect for several days. With an increase in body temperature and the appearance of flu-like symptoms in patients using nimesulide, the drug should be discontinued. When using nimesulide, there were reports of the occurrence of serious adverse reactions from the liver (very rarely fatal), therefore, with prolonged use of nimesulide, it is necessary to monitor liver function indicators at intervals of 1 time in 2 weeks. If patients taking nimesulide experience changes in liver function indicators (increased AlAT, AsAT, alkaline phosphatase), symptoms of liver damage appear (anorexia, nausea, vomiting, abdominal pain, dark urine), the drug is canceled and is not prescribed in the future. There have been reports of liver damage (most of which was reversible) after short-term use of the drug. During treatment with nimesulide, its combined use with drugs that have a hepatotoxic effect, as well as alcohol abuse, should be avoided, since these substances can increase the risk of adverse reactions from the liver. When treating with nimesulide, you should refrain from using other analgesics.
Nimesulide should be used with caution in patients with gastrointestinal disorders (peptic ulcer, history of gastrointestinal bleeding, ulcerative colitis or Crohn's disease). At any stage of treatment, nimesulide can provoke gastrointestinal bleeding, the appearance of a peptic ulcer or perforation of a hollow organ, regardless of whether there was a history of diseases of the digestive tract. In the event of such complications, treatment with nimesulide should be discontinued.
In patients with impaired renal or cardiac function, Nimesil should be used with caution, as it may cause or exacerbate these disorders. In this case, Nimesil therapy should be discontinued. The drug can cause fluid retention in the body, so in patients with hypertension (arterial hypertension) and heart failure, it should be used with extreme caution.
The drug may cause drowsiness or dizziness. The elderly are more likely to develop side effects when using NSAIDs, such as gastrointestinal bleeding or perforation, dysfunction of the heart, liver or kidneys, so these patients need constant medical monitoring. Nimesulide can interfere with platelet function, so it should be prescribed with caution in hemorrhagic diathesis.
Nimesil should not be used as a substitute for acetylsalicylic acid for cardiovascular prophylaxis. Nimesulide may mask an increase in body temperature associated with a bacterial infection.
During pregnancy and breastfeeding. It is not recommended to prescribe nimesulide to women planning a pregnancy. Patients whose pregnancy is complicated or women who are being examined for infertility should not take nimesulide. Nimesulide is not recommended during breastfeeding.
Influence on the ability to drive vehicles and work with precise mechanisms. Studies of the effect of nimesulide on the ability to drive vehicles and work with mechanisms have not been conducted. If dizziness or drowsiness occurs during the use of nimesulide, such activities should be abandoned.
Interactions of the drug Nimesil
Patients using warfarin or other indirect anticoagulants, or acetylsalicylic acid, have an increased risk of bleeding while using Nimesil, so this combination is not recommended, and in severe forms of bleeding disorders it is contraindicated. If such a combination cannot be avoided, regular monitoring of the state of the blood coagulation system is necessary. In healthy individuals, nimesulide temporarily reduces the diuretic effect of furosemide and the excretion of sodium and, to a lesser extent, potassium, therefore, with the simultaneous use of nimesulide and furosemide in case of impaired renal or cardiac function, special care should be taken. There is evidence that NSAIDs reduce the clearance of lithium, which leads to an increase in the level of lithium in the blood plasma and an increase in its toxicity. If Nimesil is prescribed to a patient receiving lithium preparations, frequent monitoring of the level of lithium in the blood plasma is required.
With simultaneous use with glibenclamide, theophylline, warfarin, digoxin, cimetidine and antacids, no clinically significant interactions were noted. Caution should be exercised if nimesulide is prescribed less than 24 hours before or after methotrexate, since it is possible to increase the level of the latter in the blood plasma and increase its toxicity. With simultaneous use with cyclosporine, an increase in the nephrotoxicity of the latter is possible.
Overdose of the drug Nimesil, symptoms and treatment
Symptoms: apathy, drowsiness, nausea, vomiting, pain in the epigastric region. These symptoms are usually reversible. Gastrointestinal bleeding, arterial hypertension, acute renal failure, respiratory depression, coma may occur. However, such phenomena are rarely noted.
Treatment: symptomatic; there is no specific antidote. There are no data on the elimination of nimesulide by hemodialysis, but given the high degree of binding of nimesulide to plasma proteins (up to 97.5%), it is unlikely that dialysis will be effective. Shown gastric lavage, the use of activated charcoal.
Storage conditions of the drug Nimesil
In a dry, dark place at room temperature.
List of pharmacies where you can buy Nimesil:
- St. Petersburg
Fever and acute pain require immediate intervention and effective drugs. To quickly relieve unpleasant symptoms, strong medications are often used, which include Nimesil. What the drug consists of, when and to whom it is prescribed, how to take Nimesil in order to avoid complications - answers to questions in our article.
Yellow granules of the drug are intended for the preparation of a suspension.
The active substance is nimesulide, a broad-spectrum non-steroidal anti-inflammatory drug. A single sachet with 2 grams of powder contains 100 mg of the active substance.
Auxiliary components are:
- sucrose;
- lemon acid;
- maltodextrin;
- orange flavor;
- macrogol.
Pharmacological action and indications for use
The drug acts directly on prostaglandins, reducing their ratio in the body. Since these substances serve as mediators of inflammation and pain, reducing their amount suppresses these symptoms and improves well-being.
Nimesulide acts regardless of the nature and cause of pain, the anesthetic effect lasts up to 6-7 hours. In addition, the drug inhibits inflammation, normalizes body temperature and relieves swelling.
The action of the medicine is aimed at eliminating the symptoms, and not at the cause of the disease.
Indications for use are:
- various injuries;
- pain in the spine, lower back;
- migraine;
- postoperative syndrome;
- joint pain;
- painful periods;
- radiculopathy of various origins, sciatica;
- tendinitis;
- arthritis, rheumatism.
The quick effect of "Nimesil" is often used for toothache, when it is necessary to eliminate painful sensations in as soon as possible. The need to take the drug also occurs after dental procedures.
How to take Nimesil
The drug irritates the mucous membrane of the digestive system, so it should be taken after meals. Immediately before use, a suspension should be prepared from the powder, which is not intended for long-term storage.
How to dilute Nimesil powder
- Open the sachet with granules, pour into a cup or glass.
- Add a hundred milliliters of clean warm water to the dishes. It is necessary to dilute "Nimesil" with water at about 36 degrees.
- Shake until a homogeneous consistency is formed.
The suspension is ready for use.
Dosing regimen
Children under 12 years of age are prohibited from taking nimesulide due to the high toxicity of the drug.
The maximum dosage for adult patients is 100 mg (1 sachet) twice a day.
If the analgesic effect lasts longer, you can reduce the amount of the drug, but in no case increase it.
Symptomatic treatment can last no more than 14 days. If the drug does not help, you should consult a doctor for advice.
During pregnancy and lactation
High toxicity and the ability to cross the placental barrier puts the drug on the list of prohibited drugs for women expecting a baby.
If during the first two trimesters of pregnancy, in some cases, doctors prescribe a short course of nimesulide to eliminate painful symptoms, then in the third trimester this is excluded.
After all, the medicine causes certain risks for the expectant mother and child:
- decreased kidney function;
- changes in blood pressure;
- oligohydramnios;
- premature closure of the arterial duct;
- decreased contractility of the uterus;
- increased swelling;
- bleeding;
- deviations in the development of the child.
Taking nimesulide through breast milk will only harm babies. Therefore, nursing mothers should abandon this method of eliminating pain and choose another drug.
drug interaction
You can not combine nimesulide with such drugs:
- diuretics, antiarrhythmic and antihypertensive drugs - their effectiveness decreases;
- other NSAIDs, lithium-containing drugs - side effects are aggravated;
- anticoagulants and corticosteroids - the risk of internal bleeding and mucosal irritation increases;
- ACE inhibitors and cyclosporine - the toxic effect on the kidneys and liver is aggravated;
- Furosemide - causes accumulation of sodium and potassium, metabolism becomes more difficult.
Contraindications, side effects and overdose
The high efficiency of the drug under discussion indicates its increased toxicity.
Therefore, in the instructions for use, in addition to the standard hypersensitivity to the components of the drug, an impressive list of contraindications is indicated.
Namely:
- age up to 12 years;
- pregnancy;
- lactation;
- fever in acute respiratory diseases;
- kidney failure;
- gastric ulcer in the acute stage;
- severe liver pathology;
- internal bleeding;
- stable arterial hypertension;
- chronic alcoholism;
- heart defects;
- diabetes;
- the period after coronary artery bypass surgery;
- pathology of blood clotting;
- hyperkalemia.
In addition, along with an effective effect on the source of pain, the drug causes unwanted symptoms, disrupting the activity of other systems.
Possible reactions:
- dyspepsia phenomena - stomach pain, urge to vomit, bloating, disorders;
- general weakness, fatigue, anemia, dizziness;
- pressure surges, hypertension;
- swelling, itching, urticaria, peeling of the skin;
- hyperhidrosis;
- hematuria, problems with urination;
- renal and hepatic insufficiency;
- bleeding in the digestive tract, ulcer;
- muscle spasms;
- blurred vision;
- panic state, rapid excitability, insomnia;
- breathing problems, bronchospasm;
- decrease in body temperature.
An overdose threatens with unpleasant symptoms from the digestive system (nausea, pain and even bleeding), general weakness and apathy, as well as a sharp increase in blood pressure. At a significantly increased dose, a person can fall into a coma.
Cheap analogues of Nimesil
The cost of the described medication is quite affordable for consumers. In addition, in addition to this drug, there are other drugs with nimesulide.
Among them:
- "Flolid" in suspension, tablets or granules;
- "Aponil" in tablets;
- "Nise" in pills;
- "Aktasulide" in tablet form;
- "Nemulex" in granules;
- pills "Prolit";
- "Nimesan" in the form of tablets.
Some drugs are complete analogues in terms of the amount of active substance, while others have a different ratio of nimesulide. This changes the indications and prohibitions on the use of medicines.
If, for any reason, it is necessary to choose another remedy from the NSAID group, the range of drugs is wide. The choice depends on the genesis and characteristics of pain.
Relieve pain and inhibit inflammation:
- "Diclofenac";
- "Sinart";
- "Meloxicam";
- "Artromax";
- "Mukosat";
- "Glucosate";
- "Moveks";
- "Ibuprofen";
- "Chondroxide";
- "Aspirin".
Tablets, ointments, gels, capsules and granulates - various shape drugs allows you to choose the best option for each individual case in order to quickly and effectively eliminate pain.