Nitroglycerin for high blood pressure. Method of using nitroglycerin at high pressure and its effect on the body Does nitroglycerin lower blood pressure

Consider how Nitroglycerin affects the human cardiovascular system: it increases or lowers blood pressure, why is the drug needed?

Nitroglycerin is an antianginal agent that causes the release of active nitric oxide in vascular smooth muscle. It has several forms of release - tablets, spray, injection.

Composition and pharmacological properties

The active ingredient of the drug is the substance of the same name nitroglycerin. Its action is aimed at:

myocardial oxygen saturation;
normalization of coronary blood flow;
myocardial unloading.

The main indications for taking the medicine are the following conditions:

removal / prevention of angina attacks;
myocardial infarction;
insufficiency of the left ventricle;
recovery after myocardial infarction;
unstable angina;
pulmonary edema.

The therapeutic effect of Nitroglycerin is observed 1-3 minutes after application. The maximum concentration in the blood reaches 20-25 minutes. Excreted from the body by the kidneys, gastrointestinal tract.

Effect on pressure

Nitroglycerin lowers blood pressure. This effect acts as a side effect of the drug. Since the drug expands the lumens of the coronary vessels, blood circulation improves, the level of blood pressure falls.

However, the effect of the drug is incomparable with the action. Therefore, the use of nitroglycerin for the treatment of hypertension is impractical.

But, despite this, doctors often prescribe a remedy for hypertensive patients. This is done to avoid the development of heart attacks, ischemia, angina pectoris (these diseases are frequent companions of hypertension).

Nitroglycerin gives a side effect in the form of a decrease in blood pressure, the dosage of antihypertensive drugs is adjusted. Their dose is reduced, since the simultaneous use of these medications can provoke a hypotensive crisis.

Application methods

The dosage of the drug is selected individually. Classic treatment regimen:

tablets - 1 piece under the tongue 2-3 times / day;
spray - 2-3 sprays in the oral cavity 2-3 / day;
solution for injection - is administered intravenously, slowly using an automatic dispenser or infusion, after diluting the contents of the ampoule with 5% glucose solution.

Adverse reactions

Reception of Nitroglycerin can provoke the appearance of the following adverse reactions:

headache;
dizziness;
tachycardia;
sensation of a rush of heat;
cyanosis;
nausea, vomiting;
psychotic reactions;
skin rash, itching.

If adverse reactions occur, you should immediately stop taking the drug, visit a doctor.

Contraindications

Contraindications to the use of the drug are:

collapse;
hypotension;
acute myocardial infarction, accompanied by a sharp decrease in blood pressure;
constrictive pericarditis;
increased intracranial pressure;
pulmonary edema of toxic origin;
cardiac tamponade;
hypersensitivity to active components.

"Nitroglycerin" has a positive effect on blood vessels, eliminating spasms, stops angina attacks. Nitroglycerin is prescribed as a fast-acting drug for pressure - as a result of taking the drug, blood pressure decreases. Many other favorable properties of this remedy on the human body have been established. Let's consider how effective the action of "Nitroglycerin" is for lowering pressure indicators, and how the drug affects the patient's health.

How does Nitroglycerin work?

The beneficial effect of "Nitroglycerin" is carried out due to the active ingredient - glycerol trinitrate, which contains nitrogen in its composition. It binds with oxygen to form nitric oxide (NO). This compound promotes smooth muscle relaxation by activating the production of guanylate cyclase. Such an action is accompanied by the removal of spasm, a decrease in the load on the heart, vasodilation, an improvement in blood flow, and metabolic processes.

"Nitroglycerin" at high pressure, helps to lower it, has an effect on the body:

increases the lumen of blood vessels;
relieves pain in the chest, heart;
helps to eliminate spasm of smooth muscles of the gastrointestinal tract, coronary arteries.

"Nitroglycerin" under reduced pressure is contraindicated, since with its help the opposite effect is achieved.

Often, the substance is used for angina attacks to stop pain in the chest area.

Main types

The drug is rapidly absorbed from the skin and the surface of the mucous membranes. The effect of "Nitroglycerin" is observed 1-2 minutes after it enters the bloodstream. However, the duration is just as short (up to an hour).

To increase the duration of action of the drug, prolonged action agents are used. The active substance (trinitroglycerin) is enclosed in granules, which are then coated. Due to this, trinitroglycerin is not released immediately (after 15-20 minutes), gradually, in parts, which allows you to extend the effect of the drug up to several hours.

Release forms

"Nitroglycerin" is produced in different forms:

sublingual tablets (dosage 0.5 mg, 20, 40 pieces);
capsules (the dosage is the same as for tablets, in addition to the main substance, it contains 1 mg of a 1% oil solution);
1% alcohol solution, used as drops (volume 5, 10 ml);
sublingual spray (1 dose - 0.4 mg);
concentrate for solution preparation and intravenous administration (1 mg/ml, volume of ampoules 2, 5, 10 ml);
prolonged-release tablets (coated);
patch;
ointment.

Excellent medicine to help the heart muscle cope with excessive stress

Indications for use

There are a number of diseases in which "Nitroglycerin" is prescribed. Its use can be both long-term and one-time. The main target of the drug is the cardiovascular system.

However, in addition to heart disease, the drug is used for:

biliary colic;
acute pancreatitis;
spastic colitis;
intestinal dyskinesia;
spasm of the arteries in the retina;
pulmonary edema.

Indications for the use of "Nitroglycerin" for the heart

"Nitroglycerin" for a short time allows you to stop and prevent vascular spasms of the smooth muscles of the heart.

It is prescribed in the treatment of cardiovascular diseases:

angina pectoris, for the relief of pain in the chest;
heart failure;
hypertensive crisis, accompanied by pain in the heart;
acute ischemic necrosis;
neurosurgical operations to artificially lower blood pressure.

In addition, the drug can be used as a prophylaxis to reduce the risk of developing angina pectoris caused by stress or physical activity.

Nitroglycerin relieves not only heart pain, but also eliminates spasms of smooth muscles of the gastrointestinal tract

Does nitroglycerin increase or decrease blood pressure?

The opinion that Nitroglycerin increases blood pressure is erroneous. However, its use has an impact on blood pressure indicators. Removal of spasm of blood vessels is accompanied by their expansion, which entails a decrease in pressure.

Lowering the pressure is not the main property of the drug, but rather only a side effect. "Nitroglycerin" is used to prevent stroke, myocardial infarction, aortic aneurysm, with high blood pressure (even in the absence of chest pain).
When using it, a short-term decrease in pressure may be observed, which will entail weakness, dizziness, increased heart rate, and fainting. Therefore, after taking the drug, it is better to rest. This will help to temporarily reduce pressure and normalize the patient's condition until medical attention is received.

Admission rules

To protect the body while taking the drug and maintain its effectiveness, you should follow some recommendations (rules):

It is not worth using nitroglycerin at high pressure with the sole purpose of lowering pressure.

Tablets or capsules should be placed under the tongue and wait for complete dissolution. To reduce this time, the capsule can be cracked. If within a few minutes the condition does not improve, it is recommended to re-use the product. If there is no improvement, seek medical attention. The next dose can be taken no earlier than half an hour later. This time is enough for the previously taken dose to be removed from the circulatory system. The maximum daily intake should not exceed 5-6 tablets.

Alcohol solution either drip directly under the tongue (2-4 drops), or apply the same amount on a sugar cube and put under the tongue until completely dissolved. 16 drops is the maximum amount allowed per day.

Spray (1-2 doses) spray under the tongue in a sitting position. Sit for a few seconds with your mouth closed, do not swallow. If necessary, the procedure can be repeated, but not more than 3 times in 15-20 minutes.
Dilute the intravenous solution in 5% glucose solution or 0.9% NaCl to obtain a concentration of 50, 100 µg/ml. Administer by drip. If necessary, for the appearance of the effect, you can increase the dosage (every 5 minutes) or the rate of administration (up to 0.02-0.01 mg / min).
Stick the patch on the skin for 12-14 hours. After removing the patch, take a break of 12 hours.

How to take: instructions for use for various indications

To stop an acute attack of angina pectoris, one of the forms of the drug should be taken:

Prolonged use of "Nitroglycerin" can be addictive

tablet - about 5 mg;
alcohol solution - 2-3 drops;
aerosol - 1-2 doses.

As a prophylaxis for an angina attack:

tablets - 0.5 mg a couple of minutes before going outside, start physical activity;
spray - 1 dose, 5-10 minutes;
use the patch on the chest or upper arm (it is recommended to change the area the next time the patch is applied);
ointment - apply a thin layer of 5-10 cm on the skin of the chest, abdomen of the hands (repeat 2-3 times a day).

With myocardial necrosis, administer the drug intravenously (5% solution).

To eliminate pulmonary edema:

aerosol - 4 doses;
intravenously (1% solution).

For pancreatitis, hepatic colic, use 1 dose of the tablet form of the drug.

Contraindications and side effects

Contraindications for the use of "Nitroglycerin" are:

The drug is not used for myocardial infarction, glaucoma, during pregnancy and breastfeeding

Individual intolerance to drugs containing nitrates.
Age (up to 18 years).
Pregnancy, breastfeeding.
Low pressure.
Circulatory disorders.
Simultaneous use of phosphodiesterase inhibitors.
Collapse.
Violation of the functionality of the liver and kidneys.
Pulmonary edema due to exposure to toxins.
Heart disease.
Angle-closure glaucoma.
Epilepsy.

When using the drug "Nitroglycerin" side effects are possible:

dizziness;
headache;
pain in the stomach;
tachycardia at low pressure;
diarrhea;
nausea;
feeling of anxiety;
disorientation;
sensation of heat;
noise in ears;
dry mouth;
allergic reaction;
cyanosis (cyanosis of the skin and mucous membranes).

The substance dilates the blood vessels, because of this, the patient may experience a headache after taking it.

Storage rules

It is necessary to store the drug in a cold dark place (heat and light contribute to the rapid destruction of the active substance). When using, you should immediately close the jar, the container and cotton wool are treated with a special solution to preserve the activity of the product.

Features of use

"Nitroglycerin" is a fairly common remedy. The drug has a fast action and is able to lower blood pressure for a short time.

Some rules for the use of "Nitroglycerin" for hypertension should be taken into account:

It is necessary to use the drug to lower the pressure while lying down or sitting (due to the rapid expansion of blood vessels, dizziness, fainting may occur).
To prevent addiction and reduce the effectiveness of the drug, it is necessary to take breaks in its use.
During the use of "Nitroglycerin" it is necessary to refuse to drink alcoholic beverages.

increasing weakness;
decrease in blood pressure;
an increase in blood methemoglobin;
shortness of breath and burning in the throat;
puffiness on the skin;
the development of cyanosis (the appearance of blue areas on the skin);
hypothermia;
ischemia, the development of a heart attack with a sudden fatal outcome is not excluded.

The drug belongs to toxic substances, since absorption through the mucous surface occurs quickly. The volume of the drug that can cause poisoning with "Nitroglycerin" ranges from 25 - 75 mg.

What to do with a pressure of 200 to 110

Pressure 200/110: hypertensive crisis
What to do with a hypertensive crisis
Complications of pressure 200110
What if it's not hypertension?

High blood pressure is one of the symptoms of hypertension. It can be momentary (raise due to physiological or stressful reasons) or permanent. If the upper blood pressure indicator approaches 200, this indicates a hypertensive crisis, the need for emergency medical care. What to do with a pressure of 200 to 110? Call a doctor or just give a pill to reduce pressure?

Pressure 200/110: hypertensive crisis

Arterial pressure 200/110 corresponds to the 3rd degree of hypertension. It is accompanied by sharp painful sensations:

Severe pain and "pulsation" of the head;
Digestion is disturbed, the person is sick;
Blood rushes to the head: the skin of the face turns red, small vessels in the eyes burst;
Vision is impaired: flies flash before the eyes;
There is a strong heartbeat.

In addition to grade 3 hypertension, pressure 200/110 may occur in the earlier stages of the disease, during hypertensive crises. A crisis is a sharp increase in blood pressure, a jump up by 30-40 or more mm Hg. Art.

What to do with a hypertensive crisis

The very first thing with a pressure of 200/110 is to dial an ambulance and call a doctor. While waiting for the doctor, you can give the sick person drugs to reduce pressure. And be sure to write down what and how much the patient received.

What to do at home with a hypertensive crisis, if you decide to wait for the doctor to arrive:

Take blood pressure medicine (the one prescribed by the doctor as an emergency dose). Among them are indapanide, hypothiazide, chlorthalidone.
For pain in the heart area - give nitroglycerin (under the tongue).
Lay the patient on a sofa or bed, or seat in a deep chair. Head - lift and put on a pillow (or a roller twisted from things). With a hypertensive crisis and high blood pressure, fainting and dizziness are possible.
If a person shivers from cold (often high blood pressure accompanies severe chills), it is necessary to attach a heating pad with hot water to his legs, put mustard plasters.
The patient should breathe deeply and slowly. This helps to restore breathing and slightly reduce pressure.
In the presence of a tonometer - it is necessary to measure the pressure every 15-20 minutes. To track the development of the process - the pressure is kept at a stable high level, jumps or slowly decreases.

Complications of pressure 200110

High blood pressure is dangerous with a number of serious complications. What can a hypertensive crisis lead to, and why is it necessary to urgently reduce high blood pressure?

A rupture of blood vessels is possible - it occurs in the most depleted parts of the vessels, or where high pressure is localized (in cardiac hypertension, pressure is localized in the region of the heart, it can also be localized in the brain, kidneys). Possible: stroke (rupture of a vessel in the brain tissue), heart attack (rupture of a vessel in the region of the heart), internal bleeding. Stroke and heart attack are life-threatening conditions. They can be fatal.
Pulmonary edema.
Renal failure (develops with high renal pressure).

What if it's not hypertension?

Hypertension is understood as a persistent increase in pressure relative to normal values (the norm is 120/80, increased is 130/95 mm Hg, anything higher is hypertension). It is against the background of constant elevated blood pressure that hypertensive crises occur. During a crisis, the pressure increases sharply, and the state of health worsens.

In addition to hypertensive crises, blood pressure indicators may increase with certain diseases and changes in atmospheric conditions. Let's list under what:

kidney disease;
brain diseases;
endocrine diseases;
Poisoning with alcohol, drugs, tobacco, as well as some drugs, diet pills;
Spinal cord injury.

Doctors call hypertension the "silent killer". This disease can proceed unnoticed, with a minimum number of symptoms. And manifest themselves - at the first hypertensive crisis.

If the process has gone too far, the crisis that has occurred may be the last. Therefore, if these symptoms of high blood pressure appear, you should immediately call an ambulance.

Nitroglycerin under pressure

The scope of "Nitroglycerin" are emergency conditions in cardiology, gastroenterology, surgery. "Nitroglycerin" for the heart provides first aid for an attack of angina pectoris, and it also saves from heart pain, lowers high blood pressure. Restores the heart with its functional insufficiency.

Indications for the use of "Nitroglycerin" for the heart

Manifestations of angina pectoris in the form of an acute attack, to avoid the latter;
in acute ischemic myocardial necrosis as a means of pre-medical measures, and during recovery;
heart failure;
pulmonary edema;
from pain in the heart during a hypertensive crisis;
with a deterioration in the motility of the biliary tract, intestines;
at elevated pressure;
acute pancreatitis;
during operations in neurosurgery artificially lowers blood pressure.

General admission rules

The medication can only be taken as prescribed by a doctor.

"Nitroglycerin" is taken exclusively on prescription, strictly observing the dosage. In addition, it is worth considering the combination of "Nitroglycerin" with other medicines. There are some general rules of admission that will increase the effectiveness of treatment and alleviate unpleasant side effects:

Due to the instantaneous expansion of the cerebral vessels, the use of the drug causes a sharp pain in the head. The feeling disappears after a few treatments.
To achieve the fastest effect, taking "Nitroglycerin" is required in tablet form, I place the drug under the tongue (sublingually).
"Nitroglycerin" at high pressure is desirable to take in a sitting or lying position, because due to the rapid vasodilating effect and pressure reduction, dizziness and fainting occur.
Long-term use reduces the effect of the drug, addiction occurs. You need to take a break for a month to restore sensitivity.
If during an attack of angina the pain did not go away a few minutes after taking the medicine, another dose is indicated with an interval of 5 minutes, but not more than 3 times in 15 minutes.
During therapy, alcohol is prohibited. "Nitroglycerin" in combination with alcohol can provoke a collapse.
"Nitroglycerin" reduces pressure and reaction rate, so drivers and representatives of professions that require attentiveness and composure should be careful.

If after taking 3 doses of "Nitroglycerin" with an interval of 5 minutes, the condition does not improve, you should call an ambulance to prevent myocardial infarction.

When should you not use Nitroglycerin?

Drinking "Nitroglycerin" is not allowed for children and adolescents, the elderly, pregnant and lactating women. Instructions for use of the drug notes the conditions in which taking "Nitroglycerin" is dangerous:

"Nitroglycerin" is contraindicated during pregnancy.
after a brain, cranial injury or stroke (increases pressure inside the skull);
under reduced pressure due to the danger of fainting and collapse;
nitrate intolerance;
glaucoma;
heart defects;
insufficiency of liver or kidney function;
swelling of the lung tissue caused by damage to toxins.

Side effects

Therapy with medicines with glycerol trinitrate is accompanied by unpleasant phenomena in different body systems. Common side effects from the vascular system and the heart, less often - digestion. The nervous system reacts more often to excess doses. Side effects:

a rapid drop in blood pressure;
tachycardia with low blood pressure;
a flush of heat and redness of the face;
unbearable pain in the head;
bluish skin and mucous membranes (cyanosis);
pain in the stomach;
nausea, vomiting, diarrhea;
anxiety or lethargy;
problematic spatial orientation;
dermatitis.

Analogues of "Nitroglycerin"

Drugs similar in pharmacological effect and indications are called analogues. They may differ in quantitative composition, have additional components, a lower price. Analogues are prescribed in case of a decrease in the effectiveness of the drug, due to the development of tolerance. In case of individual intolerance, the medication is replaced with an analogue or another is prescribed.

Only a doctor can choose the right analogue of nitroglycerin for effective therapy.

List of analogues: Nitrogranulong, Nitrocontin, Nitromax, Dikor Long, Isodinit, Isoket, Nitrosorbide, Trinitrolong, Sustak-forte, Nitrocardiol, Glonoin, Nitromint, Trinitrin, Nitrokor, Nitro-Mac, Nitrosprint, Nitradisk, Nitro-Nick, Perlinganite, Anginin, Angiolingval, Nirmin, Kardiket- Retard.

How to use the drug correctly

Nitroglycerin can be used to treat angina and other heart conditions in a variety of ways. Most often, patients use the tablet form of the drug.

If a pain syndrome occurs, it is recommended to put a capsule or tablet of nitroglycerin under the tongue and keep it there until completely absorbed. The dose of the drug is 1 mg per dose. Most often, this is enough to stop an attack of angina pectoris. In 65-70% of patients, the pain goes away within 2-3 minutes after taking the drug. If relief occurs before the drug is completely absorbed, the rest of the tablet should be spit out to avoid overdose or addiction to the drug.

When an angina attack is delayed, you can use another tablet of the drug, but experts do not recommend exceeding this dose. A prolonged attack of pain in the region of the heart may indicate the development of acute myocardial infarction, when specialized assistance should come to the patient already in the first hour of the disease.

The duration of action of conventional nitroglycerin when taken sublingually is no more than 45 minutes. Addiction to simple nitroglycerin is a rather rare occurrence, but if it occurs, then the dose of the drug has to be increased by 2 times.

In addition to tablets and capsules, the modern pharmaceutical industry produces a wide range of different tablets with a selected dose of medicine. There are plates for gluing in the oral cavity and for external use.

If the drug is used as a skin patch, then the initial dose is 0.2 mg or one TTC 5 patch per day. The maximum daily dose for this method of treating angina pectoris and acute necrosis of the heart muscle is 0.8 mg. Given the rather high toxicity of nitroglycerin, such therapy is usually carried out in a cardiological hospital under the supervision of physicians.

There are also ointments and spirea with nitroglycerin for the relief of pain in the region of the heart. These dosage forms have not yet become widespread, and nitroglycerin tablets and capsules are in greatest demand. The drugs "Nitrospray" and "Nitrospray-ICN" are in demand in the pharmacy network. The weak distribution of the spray and ointment is due to the complexity of the dosage and the possible allergic reaction to these types of nitroglycerin.

Long-acting nitroglycerin and its analogues

If the patient has developed an acute attack of angina pectoris, then the most suitable drug for its relief is simple nitroglycerin. However, there are situations when nitrates are included in the IHD treatment regimen, so their long-term use is required.

In such a case, most specialists prefer other drugs. In the medical literature, they are known as long-acting nitroglycerin, the names of these drugs are found in most reference books on the treatment of heart disease:

The main of this group of drugs is "Sustak". This form of nitroglycerin may contain 2.6 mg of the drug or 6.4 mg. Depending on the dosage, the drug is produced in 2 types: "Sustak-Mite" and "Sustak-Forte". The therapeutic effect of this medicine occurs 60 minutes after ingestion and lasts more than 10 hours. The dosage depends on the severity of the patient's condition and the duration of the disease of the coronary vessels. The drug has an analogue - "Sustonit". It is less effective, therefore it is recommended to increase the dose for the treatment of angina pectoris by 1.5 - 2 times.
Among the prolonged nitrates, newer drugs such as Nitrong and Nitrogranulong are very popular. The mechanism of action of these nitroglycerin substitutes is practically the same as Sustak, daily dosages are slightly adjusted. In the treatment regimens for coronary heart disease, these drugs are recommended to be taken 3 times a day for 3 to 4 weeks. The control of a cardiologist in the treatment of prolonged nitroglycerin is required.
AT recent times isosorbite mononitrate is widely introduced into medical practice. This medicinal substance corresponds in its medicinal properties to nitroglycerin, but is less toxic. "Medokor" and "Monoket" (advertising names of the drug) are recommended by many cardiologists for permanent use in CHF.

Prolonged nitroglycerin has proven itself well in chronic pathology of the heart muscle, however, in acute forms of angina pectoris and myocardial infarction, conventional nitroglycerin cannot be dispensed with.

Taking any medication should be discussed with your doctor. The specialist will definitely advise the best option for solving a health problem, tell you the dose and duration of taking this medication.

This will help to avoid side effects and overdose in the treatment of angina pectoris and other heart diseases.

How to take nitroglycerin

If you have had heart pain at least once in your life, you have come across a recommendation to take nitroglycerin. This drug has been used in cardiology for over 100 years.

It was invented in 1847 as an explosive and was used in the factories of Alfred Nobel, in 1880 - nitroglycerin was used as part of photographic film and for x-rays.

Today it is a medicine that the World Health Organization classifies as life-saving. What happens in the human body when he takes nitroglycerin tablets for pain in the heart?

Heart attack

What is a heart attack? And why do they take nitroglycerin for heart pain? With narrowing of blood vessels and blockage of their lumen by platelets, the risk of myocardial infarction increases.

At this point, the patient takes a tablet of nitroglycerin (which dilates both venous and arterial vessels at the same time), it turns into nitric oxide in the body, which together leads to vasodilation.

The blood begins to circulate in full and the person comes into a state of relief, the attack goes away.

Due to the fact that the venous vessels expand, the blood returns to the heart less, that is, it does not overstretch. And by reducing the tone of the artery, a person’s pressure decreases (which is a side effect of nitroglycerin) - in this case, the heart is easier to “throw out” blood. The entire cardiovascular system switches to a more economical mode of operation, that is, it consumes less oxygen.

The first aid kit must contain the drug nitroglycerin. It will help to quickly stop heart pain and restore the functioning of the cardiovascular system. In no case and under no circumstances should you endure heartache.

Rules for taking nitroglycerin

Rinse your mouth with plain water;
Put the tablet under the tongue;
Be sure to sit down - you may feel dizzy at the moment when the pill begins to act;
If you feel a tingling sensation in the mucosa (in the place where you put the pill) - this is normal, then the drug is working;
Do not take more than 3 nitroglycerin tablets more than 15 minutes apart;
If the pain in the heart does not go away 5 minutes after taking the first pill, be sure to call an ambulance.

Important! Nitroglycerin will not help people with Asian genes due to the fact that this genotype does not have the enzyme alcohol dehydrogenase in the blood (this is a substance that promotes the absorption of alcohol into the blood). By the way, in the absence of this enzyme, it is highly undesirable for a person to drink alcoholic beverages.

For the reason that alcoholism begins to develop rapidly.

Doctors recommend thus checking whether your body will respond to nitroglycerin or not. If your face turns red after drinking alcohol, then the medicine will not help (there is no alcohol dehydrogenase enzyme in the blood). In this case, you need to take other drugs for heart pain.

It is advisable to store nitroglycerin in a dark place where there is no moisture (tablets are hygroscopic, they absorb moisture).

Can I take a nitroglycerin tablet beforehand? For example, in those cases when there is a long climb to the 5th floor and you know for sure that on the last floor you will be disturbed by pain behind the sternum? Cardiologists do not forbid doing this - it is better to prevent narrowing of blood vessels in time than in a panic, suffocating, looking for nitroglycerin tablets in a bag.

Contraindications

A history of stroke and acute myocardial infarction;
low blood pressure;
Glaucoma (as a result of taking nitroglycerin, intracranial pressure may increase);
angina;
Liver failure;
Pregnancy and lactation.

Side effects

After taking nitroglycerin, headaches, dizziness, disruption of the gastrointestinal tract, anxiety, drowsiness and inhibited reaction are possible.

Analogues of the drug: Angibid, Nitrangin, Nitrocardiol, Trinitrol, Nitraangin, Glyceryl Trinitrate.

The effect of citramon on blood pressure does it lower it

Among the many different medications, there are those that are most in demand by the population. One of them is citramon. This remedy is known to so many generations of people that there is probably no person who has not heard its name. But despite such popularity of the drug, not everyone knows its true effects and purpose. In particular, people do not always correctly understand what citramon actually does - does it increase or decrease blood pressure?

A little about the composition of the drug

We must not miss the question of the components that make up this drug, since this is the essence of its action on the human body. It refers to complex tools formed by combining three components:

Acetylsalicylic acid;
Paracetamol;
caffeine.

From these names, the main purpose of the drug Citramon becomes clear - an analgesic and anti-inflammatory effect. But due to caffeine, it can also affect blood pressure levels. From the considered composition, the statement of some people that citramone lowers blood pressure becomes absolutely incomprehensible. After all, everyone knows about the stimulating effect of caffeine on the human body, in particular on the heart and blood vessels.

There are different forms and dosages of the drug. Among them, prolonged (extended), lightweight, standard dosage formulations are distinguished. In addition, it includes various combinations of other means.

Therefore, it is very important to first familiarize yourself with the doses of active ingredients and instructions for use before using Citramon.

Citramon as a remedy for headaches

Headaches have recently been disturbing almost every person, regardless of gender, age and other individual characteristics. Almost everyone associates their appearance with the fact that blood pressure changes. In most cases, this is indeed the case.

Citramon, as an excellent remedy for headaches, is the only effective medicine for many people. But before using it, it is better to measure blood pressure. This is due to the fact that citramon does not lower, but raises it, which not everyone knows about. This effect is provided by caffeine in the composition of the drug. It causes spasm of the vessels of the brain and other organs, which instantly relieves headaches, but at the same time increases blood pressure.

Citramon under reduced pressure

Due to the progression of hypertension among the population, almost every second drug lowers blood pressure. Although there are cases when there is a need for a completely opposite effect - its increase. And there are not so many tools that have such an effect. Citramon belongs to one of them. It is easiest to get at a pharmacy and use in an emergency because it is available without a prescription and almost everyone has it. Thanks to the caffeine contained in its composition, an excellent tonic effect is achieved in a short time after taking the drug. Thus, it is possible to eliminate the condition that lowers blood pressure.

Contraindications

It is better not to take Citramon if you:

High blood pressure;
Any forms and manifestations of hypertension;
Diabetes mellitus and diabetic angiopathy;
Atrial fibrillation;
Any form of tachycardia;
Increased nervous excitability and intracranial pressure;
Obliterating diseases of the arteries of the lower extremities, accompanied by their blockage, since it reduces the intensity of blood flow in them;
Ischemic stroke and other cerebrovascular disorders of the ischemic type;
Active phase of peptic ulcer of the stomach or duodenum;
Ischemic heart disease and angina pectoris, even if there is low blood pressure;
Heart failure;
Circulatory disorders in the intestines and kidneys.

Low heart pressure and high blood pressure

Chicory and pressure: increases or decreases?

Joint treatment
weight loss
Varicose veins
Nail fungus
Fight against wrinkles
High blood pressure (hypertension)

High pressure

With increased pressure, the drug should be taken in accordance with a specific scheme. If you take too large a dose, the fall will occur very rapidly. Low level pressure is accompanied by loss of consciousness. So when a person experiences severe stress or exposes itself to great physical exertion, the body responds with pain in the myocardial region, which does not stop within a few minutes. In this case, the tablet is put under the tongue, the same is done with the capsule. Due to the fact that the dosage form dissolves quickly and penetrates into the blood. After a minute and a half, the drug begins to produce a therapeutic effect that lasts up to half an hour. Then the substance breaks down and is excreted from the body. Pressure reduction is not the main property of the drug. Other drugs can lower blood pressure, but they do not do it within a few minutes.

Since the drug acts instantly, the patient may experience an attack of dizziness, up to loss of consciousness due to slight hypoxia of the brain. Therefore, it is better to immediately seat the patient or lay him on the bed. Especially, this rule should be strictly observed if assistance is provided to an elderly person. Blood pressure decreases due to the fact that the arteries and veins expand throughout the body. But the effect itself works for a very short time.

Sometimes pain with localization in the cardiac region can also occur at rest. In this case, nitroglycerin is taken in the same way and according to the same scheme as for pain caused by physical and emotional stress. Take the drug when stopping an attack in large quantities it is impossible, if the pain does not go away for another two minutes, then you can take three more tablets with an interval not exceeding five minutes.

Further, if no positive shift is noticed in the patient's condition, it can be assumed that myocardial infarction is developing. In this situation, it is required to deliver the victim to the hospital as soon as possible. If there is a risk of developing a heart attack, doctors can use nitroglycerin in solution intravenously. But before giving an injection, nitroglycerin is given in the traditional way.

Storage

Nitroglycerin is a rather unstable compound, which, when exposed to light and heat, decomposes and becomes unusable. Therefore, the drug must be kept in the refrigerator. Definitely in the package. If we are talking about drops, then they must be stored in the bottle in which it was sold at the pharmacy. Such vials are produced with certain properties that allow extending the life of the medicine. After opening the vial, the drug can not be stored for a long time. Its beneficial effect is decreasing every day. For a month, the effectiveness of the drug should decrease by 30%. Therefore, if the patient does not use the drug so often, it is better to prescribe it in capsules or tablets, which must also be stored in the package. There is another form of release of nitroglycerin in the form of a spray. This form is more convenient to store, and it is intended for emergency assistance.

At the first dose, the vessels dilate. This can cause headaches. Then, over time, the substance no longer has a similar effect in strength. But it is impossible to increase the dose, since nitroglycerin, when taken regularly, has a prolonged effect.

It is advisable to always have nitroglycerin with you during an attack of angina pectoris. And as soon as the first signs appear, the drug must be taken immediately. After the danger has passed, start taking drugs with a longer duration of action.

After taking the drug, the effect of taking the drug lasts for six hours, then the heart continues to work independently. Therefore, the patient feels a slight pain in the heart. You can not take a break in taking nitroglycerin and drink the pill in advance until the previous pill stops working. Then the pain won't come.

In addition to the active substance, the capsules contain oil, due to which the medicine will spend more time when absorbed into the bloodstream than when taking drops. Therefore, when attacking the capsule can not be used.

Nitroglycerin has another significant drawback. It is addictive. To do this, you need to take the medicine for a whole month. Therefore, the effect of taking the drug is reduced. In order for the drug to begin to benefit again, it is necessary to take a monthly break. And when taking during the day, the interval should be at least 6 hours.

Those with low blood pressure need to take nitroglycerin very carefully. A feature of the effect of the drug is a very specific visual impairment, if you look at a dark pattern on a light background, yellow and blue circles appear before the eyes.

Nitroglycerin can affect the intraocular pressure, in the direction of its increase, although it reduces the usual arterial pressure. The only way to get rid of the problem is to stop taking the drug. An overdose of nitroglycerin can lead to complete cardiac arrest. First aid in this case is to provide oxygen to the brain. It is recommended to raise your legs and vice versa lower your head. Ascorbic acid and cardioprotectors are administered intravenously. And also prescribe large doses of hormonal drugs.

It is not recommended to take the drug in order to lower abnormally high blood pressure. But despite this, the remedy belongs to those drugs that quickly lower the pressure, while eliminating the pain syndrome. That is why it is necessary to take pills for hypertension only with the permission of the doctor.

When raises

The main purpose of the drug is to relieve angina attacks, as well as pain syndrome. Tablets relieve tension from the heart muscle and relax it. Thus, they have a positive effect on high blood pressure. The action of the tablets begins 5 minutes after ingestion. If the medication was taken in the form of capsules, then the action comes a little later.

When it reduces

"Nitroglycerin" lowers the pressure in case of an overdose of the drug to the point that a person loses consciousness and cannot recover for a long time. The agent does not have a significant effect on low pressure. In case of hypotension, it is recommended to give preference to other means to increase blood pressure. "Nitroglycerin" is not among the recommended drugs for hypotensive patients.

It is not contraindicated to take the remedy at high pressure, but it is also undesirable to do it yourself without consulting a doctor. Tablets of the remedy lower the abnormally increased pressure in 3-5 minutes. With increased blood pressure, it is recommended to take the drug in the form of a spray or tablets. The action of the capsules is a little longer, unlike other forms of medication.

You need to use the remedy under the tongue. You can’t swallow it, just dissolve it until completely dissolved. An effective drug eliminates the symptoms of high blood pressure, and also quickly relieves headaches. After some time after taking the person begins to feel an improvement. While taking the medicine, you need to sit or lie down so as not to fall if you feel dizzy from Nitroglycerin.

The method of using nitroglycerin at high pressure and its effect on the body

During the treatment of high blood pressure, nitroglycerin is taken according to the following rules.

Since, at elevated pressure, the active substances of the drug can provoke bouts of dizziness and loss of consciousness, before taking a pill, you should sit down or lie down on the sofa.
If the heart has not stopped hurting, you can take nitroglycerin again, but not more than 3 tablets at a time.
For elderly and debilitated people with reduced pressure, the dosage should be reduced to 0.5 tablets. Hypotension patients should coordinate in advance the possibility of taking the medication with the attending specialist.
During treatment with nitroglycerin, the use of alcohol is excluded. Alcohol and the active substance of the drug react and provoke severe intoxication of the body.
If the medication is caused by the prevention of angina pectoris before hard physical work, the tablet should be taken half an hour before receiving the load.

The most acute manifestation of arterial hypertension and the most dangerous form of the disease is a hypertensive crisis. This attack is accompanied by a sharp jump in pressure. In such cases, first aid is provided with the help of valocordin. Nitroglycerin may help with angina symptoms. If the patient cannot open his mouth on his own, the tablet is placed under his tongue or behind his cheek.

against an attack of angina, it is enough to dissolve from half to two tablets;
the capsule of the drug contains an average single dose of the active substance;
in one day, the maximum allowable dose is 6 capsules or tablets;
one press on the aerosol head corresponds to the absorption of one tablet.

A slight violation of the dosage is not dangerous for humans, but a significant excess of the recommended norms can provoke a sharp decrease in blood pressure.

Nitroglycerin is an antianginal and vasodilator medication. It belongs to the group of medicines for the treatment of hypertensive crisis. At high pressure, nitroglycerin is able to quickly stop an attack of angina (“angina pectoris”) and lower blood pressure. Because of these properties, it is highly valued by doctors and hypertensive patients. But the effect of the drug on blood pressure is also an obstacle to the use of some categories of people with angina pectoris and some other pathologies.

Jumps in blood pressure to abnormal values torment many people. Coping with attacks is not always easy, especially if you do not know what medicine to take when you feel worse. Indications for the use of "Nitroglycerin" with increased pressure must be clarified with the attending cardiologist. After consulting a doctor, it will be clear in which case to take the medication so as not to provoke a deterioration in well-being.

The instructions for use, which is always attached to the drug, clearly spell out the dosage and application features that are recommended to be observed. If the drug is prescribed by a doctor, then he prescribes the dosage based on the patient's condition and disease. It is not recommended to take pills without consulting a doctor.

Drinking "Nitroglycerin" to improve well-being is only necessary as prescribed by a cardiologist for jumps in blood pressure. To cope with attacks of pain, the tablet is sucked. You can not swallow the drug. Dissolve "Nitroglycerin" until completely dissolved in the mouth. Take the remedy immediately after the onset of pain.

If relief does not come after 5-10 minutes, you need to take another one. The spray is also used under the tongue. For one dose, you need to press the valve 1 time so that the spray is sprayed in the mouth. Within 15 minutes, you can not use more than 3 dosages. If after 3 clicks the pain does not go away, then the remedy in this case is ineffective.

The use of a drug in a hypertensive crisis is due to a number of rules that must be followed:

With hypertension, you need to take the drug after examination by a cardiologist.
To lower blood pressure after taking the pills, you can not stand for some time. Often, after taking the remedy, a person begins to feel dizzy, and he may fall. Therefore, you need to sit down or better lie down and try to relax.
Blood pressure will return to normal, even if the heart hurts, but you need to take the drug in an amount of no more than 3 tablets at a time.
Older people and those with poor health should take half a tablet. Hypertensive patients are advised to coordinate medication with a cardiologist.
It is impossible to combine taking medicines with drinking alcoholic beverages. The interaction of the active components of the drug and alcohol causes severe poisoning of the body.

In case of a hypertensive crisis, it is recommended to drink a Valocordin tablet, and not Nitroglycerin. Its use is desirable for angina attacks and pain in the heart muscle. If a person cannot open his mouth on his own during an attack, he needs help and gently put a pill under his tongue or spray it with a spray.

Taking the remedy for a hypertensive crisis often causes dizziness. Therefore, before taking the pills, you need to make sure that the person has already taken the medication before. And if possible, it is better to replace this remedy with a medicine that is aimed at eliminating the symptoms of a crisis. In a severe case of a hypertensive crisis, an ambulance should be called.

Update date: 08/01/2018

Any disorder associated with a heartbeat or increased blood pressure is a disease that is not easy to deal with.

To facilitate the life and health of the patient, Nitroglycerin is used at elevated pressure.

The medicine has a strong effect and has a positive effect on the human body.

The tool helps to quickly cope with the state of pain, is widely used for spasms associated with improper functioning of blood vessels or the heart muscle. To stop the attack - you need to quickly take two drops of the drug and the condition stabilizes in a short time.

Letters from our readers

Kristinag. Moscow

My grandmother's hypertension is hereditary - most likely, the same problems await me with age.

I accidentally found an article on the Internet that literally saved my granny. She suffered from headaches and had a second crisis. I bought a course and checked the correct treatment.

After 6 weeks, she even began to talk differently. She said that her head no longer hurts, but she still drinks blood pressure pills. Dropping the link to the article

At first, the use of nitroglycerin was the basis of dynamite: it is a popular and well-known explosive. Nitroglycerin played the role of a huge destructive force.

But it turns out that this unique substance, taken in small amounts, can be used for oral administration at high pressure or in order to reduce the load on the heart muscle.

Nitroglycerin was obtained in the year 47 of the century before last, and its composition is quite simple:

Nitric acid;
glycerol.

It would seem that there is nothing complicated in such a compound, but what power is in this drug! The properties of this agent were first noticed by a British specialist due to the impact of its vapors on workers involved in the equipment of explosive mechanisms.

Based on the results of short-term observations, it was concluded that the medicine can be taken with a spasm of the heart muscle. The initial attacks of angina are quickly stopped, and normal heart rhythm is restored after the first dose of the drug.

So it was gradually established that "Nitroglycerin" at high pressure is able to provide effective help.

Today, the drug has an unprecedented popularity, because the result after its use is achieved incredibly quickly, and after 45 minutes it is completely eliminated from the body.

Experts have found that the use of "Nitroglycerin" is advisable in the following cases:

with pain in the chest or angina attacks;
for the purpose of preventive measures in case of possible stressful situations or depressions, the consequences of which are pain in the chest area;
in the event of spasms of the stomach and duodenum, as well as to expand the bile stream.

"Nitroglycerin" perfectly reduces high blood pressure and is used to provide first aid in crises of heart failure.

So that the result of the treatment is not long in coming, and at the same time there is an effectiveness in improving well-being, it is necessary to follow some recommendations for taking the medication.

If pain occurs in the region of the heart muscle during physical exertion on the body, half of the tablet or capsule must be placed under the tongue. The property of "Nitroglycerin" is to quickly dissolve and enter the blood stream. As a result, after half an hour, its action will be rendered.

"Nitroglycerin" is used to lower blood pressure and normalize heart function.

List of indications:

an attack of angina pectoris, which is acute;
ischemic myocardial necrosis;
violations of the functions of the heart muscle;
swelling of the lungs;
during a hypertensive crisis;
to ensure the patency of the biliary tract and intestinal tract;
with increased intracranial pressure;
pancreatitis in acute or higher stage;
to reduce pressure during neurosurgical operations.

But at the same time, it is unnecessary to make a diagnosis on your own, you should consult a specialist, and only after laboratory research The doctor will decide whether to prescribe the drug or not.

Reception features

Before taking the drug directly, you need to sit down, and it is better for the elderly to lie down, as the medication can cause dizziness and even fainting. If there is no result after two minutes, continue to drink the medicine every five minutes, but you should not use it more than 3 times in a row, otherwise you can harm the body.

If the pain does not recede, then calling an ambulance should not be postponed, since long-lasting angina pectoris will lead to a state of myocardial infarction.

The main component of the drug is glycerol trinitrate - an ester of nitric acid and glycerol, which does not increase blood pressure.

Often, the substance is used for angina attacks to stop pain in the chest area. It is advisable to use the drug to reduce the risk of developing an angina attack caused by emotional or physical stress. In addition, for the purpose of prevention, the remedy can be taken before climbing stairs or uphill, before going outside in windy, frosty weather, a few minutes before a public speech.

Nitroglycerin is used for angina attacks

Nitroglycerin stops not only heart pain, but also eliminates spasms of smooth muscles of the gastrointestinal tract, biliary tract, helps to relax the sphincter of the bile duct. This leads to its use during biliary colic, spastic colitis of the intestine, as well as in acute pancreatitis.

How does Nitroglycerin work?

"Nitroglycerin" at high pressure, helps to lower it, has an effect on the body:

increases the lumen of blood vessels;
relieves pain in the chest, heart;
helps to eliminate spasm of smooth muscles of the gastrointestinal tract, coronary arteries.

"Nitroglycerin" under reduced pressure is contraindicated, since with its help the opposite effect is achieved.

Often, the substance is used for angina attacks to stop pain in the chest area.

During the first dose of nitroglycerin, vasodilation occurs. This can give the patient a headache. With subsequent receptions, the connection no longer leads to such an effect. However, it is not recommended to increase the dosage, since with constant use nitroglycerin has a prolonging effect.

People suffering from angina pectoris should always have this drug on hand in order to stop attacks in time. As soon as the first symptoms appear, you should immediately put the pill under the tongue. When the hypertensive crisis is suppressed, you can move on to drugs that reduce pressure on a regular basis.

Pressure

After the use of nitroglycerin, the duration of the effect is only 6 hours. The heart will then continue to function unaided. In this regard, the patient may experience minor pain in the region of the heart.

In addition to the active ingredient, nitroglycerin capsules contain oil, due to which the drug will take longer to dissolve in the blood than when using the drop form of the drug. So during attacks it is better to use drops or spray.

Attention! Nitroglycerin can be highly addictive if taken for a long time. This leads to a decrease in the effect of its use. In order for the medicine to become useful again in hypertension, you need to take a break in treatment.

Patients with low blood pressure are advised to use nitroglycerin with extreme caution, since vasodilation in hypotension can lead to dizziness or fainting;
The drug has a specific effect on the organs of vision - after taking it, blue and yellow circles appear before the eyes;
The medicine can dilate the pupils, raise eye pressure, despite the fact that it knocks down the general;
Before the medical examination, you should not use this remedy;
An overdose can cause cardiac arrest - death;
When taking an overdose of the drug, you need to rinse the stomach, provide oxygen access, inject ascorbic acid into the vein and give aspirin.

Nitroglycerin does an excellent job of stopping the signs of angina pectoris and hypertensive attacks, however, combined agents that have it in their composition are more effective than a pure substance. In addition, these drugs have much less side effects. But they are slower.

If independent nitroglycerin gives an instant effect, then multicomponent preparations based on it begin to act only half an hour after the medication is received. The fact is that they must be drunk with water, and not absorbed. In an acute attack, these medicines will not help. The only exception was the analogue of nitroglycerin - Nitrosorbit, which has a fast action.

The effect of "Nitroglycerin" on pressure

Pressure

Nitroglycerin is an antianginal agent. The main actions of the drug are: expansion of blood vessels, relaxation of the biliary tract, muscles of the gastrointestinal tract and many other organs.

In addition, it redistributes blood flow in the myocardium, improves metabolic processes in it and reduces the need for oxygen.

The article will consider detailed information about the drug, as well as the answer to the question, Nitroglycerin increases or lowers blood pressure.

Nitroglycerin is prescribed for a large number of diagnoses and pathologies, namely:

treatment and prevention of angina pectoris;
spasm of the coronary arteries during CAG (coronary angiography);
chronic heart failure;
prevention of pressure increase during endotracheal intubation;
Prinzmetal's angina;
acute coronary syndrome;
high blood pressure;
arterial hypotension (under control) during the period of surgical manipulations;
unstable angina;
acute pancreatitis;
spastic intestinal dyskinesia;
acute myocardial infarction;
acute left ventricular failure;
dyskinesia of the esophagus;
cardiac asthma.

Nitroglycerin cannot be called an antihypertensive agent, although it lowers blood pressure.

The main purpose of the drug is the relief of angina attacks. The decrease in pressure indicators is extremely sharp, so this action can be called a side reaction rather than a healing property.

Following such a rapid fall, weakness and dizziness often appear, the pulse may become more frequent, coordination of movements may be disturbed, sometimes it comes to fainting. These effects disappear with time, however, after taking the medicine, it is advisable to spend a few minutes in a supine position.

Nitroglycerin is available in the form of sublingual tablets, capsules and spray:

tablets contain 0.5 milligrams, in a package there can be 20 or 40 pieces;
spray packaging is designed for 200 doses of 0.4 milligrams;
capsules contain 0.5 milligrams, the package can be 20 or 40 pieces.

All forms of release of Nitroglycerin

The country of origin of Nitroglycerin is Ukraine.

In order to stop angina pectoris, Nitroglycerin tablets or capsules must be kept under the tongue until they are completely dissolved.

To ensure the fastest possible effect, the medicine capsule can be crushed with your teeth beforehand. You can reapply the product only after 30-40 minutes. In patients with stable angina, the effect may also come from a lower dosage of Nitroglycerin, as a rule, they are recommended to take 1/2 or 1/3 tablets.

The antianginal effect of the drug is observed already after 30-120 seconds. However, exceptions are possible, sometimes it can be observed only after 3-5 minutes. In the absence of antianginal action, it is necessary to repeat the administration of this drug at a dosage of 0.5 milligrams. If in this case nothing happens, you should immediately call a doctor.

To prevent angina pectoris, it is necessary to take Nitroglycerin with the following sequence: swallow a tablet or capsule, drink plenty of water. This should be done before meals.

In mild stages of angina pectoris, it is necessary to take from 1 to 2 tablets of 2.9 milligrams 2-3 times a day.

In severe cases, 1 to 2 tablets of 5.2 milligrams are prescribed with the same amount of intake. The maximum daily dosage of this drug is 34.8 milligrams.

collapse;
childhood;
pronounced hypotension;
right ventricular infarction;
bradycardia less than 50 beats per minute;
hemorrhage in the brain;
primary pulmonary hypertension;
various head injuries;
myocardial infarction;
cerebral ischemia;
lactation and pregnancy;
hypersensitivity to the drug or its individual components;
cardiac tamponade;
toxic pulmonary edema;
severe aortic stenosis;
closed-angle glaucoma.

Nitroglycerin is stored for 3 years. After the period indicated on the original packaging of the medicinal product, it is prohibited to use it.

In Russian pharmacies, Nitroglycerin has the following cost:

tablet release form, 0.5 milligrams, 40 pieces per pack - 66 rubles;
capsule release form, 0.5 milligrams 40 pieces per pack - 19 rubles;
sublingual spray release form, 0.4 milligrams, designed for 200 doses (10 milliliters) - 103 rubles.

The drug Nitroglycerin has such analogues:

Russia: Nitrospray, Perlinganite;
Ukraine: Nitroglycerin-Health, Nitrogranulong, Nitrocontin, Nitromax, Nitro-Mik, Nitromint;
Hungary: Nitromint;
Slovenia: Nitrong;
Germany: Perlinganite.

During the period of gestation and lactation, the use of the drug is contraindicated.

Patients of childhood are not prescribed Nitroglycerin.

There is no direct contraindication to taking Nitroglycerin by the elderly, but it should be borne in mind that its poor tolerance is often noted.

At the initial stages of therapy, they are prescribed taking half a Nitroglycerin tablet under the tongue.

It should be remembered that the drug can cause fainting, dizziness, pain and heaviness in the head, as well as a sharp drop in blood pressure. Therefore, it is recommended to take the tablet in a horizontal position. With extreme caution, the drug is used in the presence of hypertension.

The combination of alcohol and Nitroglycerin can be fatal for a person.

The drug has a very rapid effect on the central nervous system, as a result of which the pain sensations recede in a short time. It also dilates the blood vessels in the brain, which can lead to headaches.

The medicine taken in the presence of even a small amount of alcohol in the body can make them unbearable. In addition, the hypotensive effect is enhanced, and the degree of intoxication may increase, which will lead to corresponding effects, for example, vomiting and disorientation.

in the 19th century, nitroglycerin was used as an explosive until it was discovered medicinal properties. He himself is considered enough effective drug when urgent assistance is needed. This mainly occurs when a myocardial infarction or an attack of angina pectoris is suspected. Often there are side effects such as headache and a sharp drop in blood pressure. Therefore, it is recommended to use a spray rather than tablets to reduce the risk of their manifestation. But if spasms in the chest are not associated with coronary artery disease, you should not use this drug at all, it will not have an effect;
of the advantages should be noted antianginal and vasodilating effect. Most often used to relieve angina attacks. On the this moment in cardiac research, Nitroglycerin in the form of a spray has proven itself best.

From the reviews of patients, it is worth noting that the drug really helps in the presence of those diseases for which it is prescribed. But in other situations, the reception threatens with many complications.

Among the advantages are low cost, availability, ease of use and quick effect. However, there are also significant disadvantages, such as death from an overdose, a large number of contraindications and side effects.

Nitroglycerin should never be used without a doctor's prescription, or at least without the presence of a disease in which it is needed. Its wrong reception threatens with serious consequences, up to a lethal outcome.

As mentioned earlier, Nitroglycerin can be found in pharmacies in various dosage forms, respectively, and the cost of the drug varies depending on its type. In pharmacies, you can find medicine in the pharmacological form of tablets, capsules, drops, sprays and ampoules.

However, as a chemical, nitroglycerin can be used for other long-acting drugs. One of the most popular means of this pharmacological group are Nitrong, Erinit and Sustak. Doctors advise taking these drugs before physical exertion, or before going out into the cold to avoid the occurrence of a sharp jump in pressure. Also, these funds are effective in preventing the onset of angina pectoris for up to 6 hours.

But, the disadvantages of these drugs include a slow effect on the body. Unlike these agents, pure nitroglycerin is characterized by rapid penetration into the body and effective fight with symptoms of high blood pressure.

Pavel Khublarov Guru (3765), closed 5 years ago

Elena Petrunina Guru (3421) 5 years ago

Side effects From the side of the cardiovascular system: dizziness, headache, tachycardia, skin flushing, fever, lowering blood pressure; rarely (mainly with an overdose) - orthostatic collapse, cyanosis. From the digestive system: dry mouth, nausea, vomiting, abdominal pain.

From the side of the central nervous system: rarely (mainly with an overdose) - anxiety, psychotic reactions, lethargy, disorientation. Allergic reactions: rarely - skin rash, itching. Local reactions: skin hyperemia, itching, burning, allergic contact dermatitis. Other: blurred vision, weakness, hypothermia, methemoglobinemia

Simultaneous use with vasodilators, antihypertensive drugs, ACE inhibitors, beta-blockers, BMCC, procainamide, tricyclic antidepressants, MAO inhibitors, diuretics, and ethanol enhances the hypotensive effect. When taken simultaneously with sildenafil, as well as with other phosphodiesterase inhibitors, a sharp decrease in blood pressure may occur.

Against the background of quinidine and novocainamide, orthostatic collapse may occur. Appointment with dihydroergotamine can lead to an increase in its concentration in the blood and to an increase in blood pressure (increased bioavailability of dihydroergotamine). The simultaneous appointment of nitroglycerin and heparin reduces the effectiveness of the latter, which may require an increase in dose (after discontinuation of the drug, a dose reduction of heparin may be required).

High pressure - causes and main characteristics

The drug is rapidly absorbed from the skin and the surface of the mucous membranes. The effect of "Nitroglycerin" is observed 1-2 minutes after it enters the bloodstream. However, the duration is just as short (up to an hour).

High blood pressure is the first indicator of the deterioration of the cardiovascular system. At the first signs of its increase, you should consult a doctor, if the symptoms of the disease are not reported in time, the process can lead to hypertension, bradycardia, and in some cases, to a heart attack, stroke, and even death.

The first signs of increased pressure:

Headache is the most basic sign of incipient hypertension. This is primarily due to the narrowing of the vessels of the brain. Especially if the headache occurs in the back of the head.
Pain in the region of the heart, which can radiate to the hand, is a sign of changes in the work of the coronary vessels and the heart muscle.
Also, the manifestation of hypertension can manifest itself in dizziness, nausea, drowsiness and a decrease in human activity, chest compression and visual impairment.
In some cases, there is pressure in the ears, sometimes accompanied by loss of consciousness.

Do not neglect the first symptoms of hypertension. The disease requires complex therapy under the supervision of the attending physician.

Contraindications and side effects

The list of diseases in which nitroglycerin is not prescribed is not at all that great. But it includes quite serious diseases.

First of all, it is high intracranial pressure. This is followed by a hemorrhage in the brain. The drug can significantly relieve blood pressure, it is not prescribed for myocardial infarction. How not to prescribe it to patients with glaucoma. You can not prescribe the drug to pregnant and lactating mothers. Nitrates can negatively affect the unborn child. In pediatrics, the drug is not used at all.

There are not many diseases that do not allow the use of this medicine. First of all, it is impossible to carry out therapy with Nitroglycerin if high intracranial pressure is diagnosed. Otherwise, the risk of intracerebral hemorrhage increases. The medicine is also not used for myocardial infarction, glaucoma, during pregnancy and breastfeeding, and is not prescribed for young children. It is not worth taking the drug under reduced pressure (hypotension), since there is a high probability of collapse or fainting.

Nitroglycerin can cause nausea

You cannot self-medicate with this remedy. During self-administration, there is a risk of exceeding the dosage, which will lead to side effects:

a sharp drop in pressure due to vasodilation;
nausea;
weakness;
abdominal pain, feeling of dry mouth;
discoloration of the skin on the face to extremely pale.

To avoid the above problems, "Nitroglycerin" must be taken only as directed by a doctor, strictly observing the dosage.

There may be pain in the abdomen

The main purpose of the remedy is to prevent and eliminate spasms of blood vessels and pain in the cardiac region, which activate an increase in blood pressure, weakness and shortness of breath. After the use of "Nitroglycerin" for 2-3 minutes, vasodilation occurs, spasms are relieved and blood pressure is significantly reduced. Due to the fact that blood pressure falls quickly and sharply, impotence, lack of coordination, dizziness can be felt.

After taking the medicine, you need to rest for a while, after which the condition will improve significantly.

"Nitroglycerin" at high pressure is used due to the following effects:

expansion of blood vessels;
decrease in venous return of blood to the heart muscle;
distribution of blood flow in the heart;
reduction of ischemic destruction;
strengthening of systolic function;
improvement of metabolic processes.

Nitroglycerin is an antianginal and vasodilator medication.

Nitroglycerin can not be taken by all patients. Contraindications include:

increased intracranial pressure;
heart attack;
pregnancy and lactation;
glaucoma disease;
problems with the organs responsible for removing toxins from the body - the liver and kidneys;
the transfer of hemorrhages and the presence of hematomas in the skull area;
incompatibility and allergy to the components of the active substance;
age up to 18 years.

In all other cases, you can take nitroglycerin without fear of dangerous consequences.

Despite the effectiveness of the drug in angina pectoris and hypertension, it also has negative qualities. The main side effects include:

dry mouth;
pallor;
nausea, pain in the stomach;
general weakness;
the appearance in the eyes of yellow spots with bluish edges when in the dark;
increase in intraocular pressure and other visual impairments;
constipation (in this case, nitroglycerin can be combined with a mild laxative or, after relieving an attack, eat a product that softens the stool: a plum or an apple).

The most dangerous consequences occur due to an overdose. In this case, the patient may experience dizziness, severe headaches. Against the background of excessive abuse of nitroglycerin, vomiting, diarrhea begins, a rash covers the skin, a person feels itching and burning.

In rare cases, the effects of treatment can affect the human psyche. Some hypertensive patients experienced psychoses, bouts of excitement, loss of orientation in space.

Feeling of dryness in the mouth.
Nausea.
General weakness, desire to sleep.
Weakness is accompanied by dizziness.
There may be pain in the abdomen.
Visually visible pallor of the mucous membranes and skin.

Individual intolerance to the drug severely limits the intake of Nitroglycerin, in the elderly the remedy can provoke constipation, then its administration is combined with gentle laxatives, preferably of plant origin.

Elevated ICP.
Hematomas in the head, hemorrhage in the brain.
Glaucoma and heart attack.
Pregnancy and HB.

AT childhood the drug is not used.

Store Nitroglycerin in the refrigerator in the "native" container. When opened, the drug quickly loses its properties, after 2 months its effectiveness is 30% lower. With a rare single dose, a medicine in the form of a spray is more suitable.

The price of Nitroglycerin is low, which makes it affordable for patients with different income levels. Available in ampoules (they are more expensive, up to 500 rubles), tablets, capsules, drops, spray.

On the basis of the chemical, the release of prolonged (long-term) action products has been launched, the most famous are: Sustak (Sustac forte), Nitrong, Erinit, Nitrosorbit. They are taken on the eve of going out into the cold, with the upcoming psychophysical stress.

These funds are able to prevent the onset of angina, which, of course, like patients who are away from home for 3-6 hours.

The biggest disadvantage of prolonged funds is the inability to quickly stop the attack (at least after 20 minutes), so Nitroglycerin in its pure form remains indispensable.

As an exception, Nitrosorbit can be noted, a sublingual remedy that acts 5 minutes after ingestion. But emergency care for an acute attack of angina should be stopped with Nitroglycerin.

Long-acting nitroglycerin preparations can be used as therapeutic drugs in the presence of heart failure. Their influence is based on a decrease in the flow of venous blood to the heart, thereby eliminating stagnation in the pulmonary circulation. But such drugs cannot give the heart muscle the necessary strength for good functioning, although they show an adequate response in cardiac asthma and the weakening of its attacks.

Facts on the subject! Currently, developments are underway to create a more modern drug that relieves pain in angina pectoris well. But so far no substance has been found that could adequately replace Nitroglycerin.

After taking nitroglycerin, the following side effects may occur:

Pain in the head;
Dizziness;
Sense of anxiety;
lethargy;
Nausea and vomiting;
Very rarely there are various allergic reactions;
If the allowable daily dose is exceeded, blood pressure may drop sharply.

It is better not to allow the alcohol solution to get on the skin, as it tends to be absorbed and provoke pain in the head.

Reception of nitroglycerin should be only with the permission of a specialist. It is impossible to cure angina pectoris with it, however, the person to whom the drug is prescribed by the attending physician should always carry it with him. This will help in time to stop the recurrence of an attack that has begun.

If nitroglycerin at high pressure is used in accordance with the doctor's recommendations, it will effectively cope with hypertension, hypotension and other symptoms of changes in the cardiovascular system. In the case of self-administration of the drug, especially in drops, you can easily exceed the recommended dose, thereby provoking the manifestation of side effects:

nausea;
dry mouth;
dizziness;
blanching of the skin;
stomach ache;
weakness.

Also, the manifestations of these and other symptoms of side effects may be affected by personal intolerance to the components of nitroglycerin by the patient's body. In the elderly, frequent use of the drug may cause constipation.

There are also contraindications to taking nitroglycerin from pressure:

The patient's intracranial pressure is above normal;
Hemorrhage in the brain, hematomas in the skull;
heart attack;
Glaucoma;
It is not recommended to use the drug for pregnant and lactating mothers;
The drug is completely prohibited for children.

In all other cases, with the correct dosage of nitroglycerin, it has an extremely beneficial effect on the body.

When raises

The main purpose of the drug is to relieve angina attacks, as well as pain syndrome. Tablets relieve tension from the heart muscle and relax it. Thus, they have a positive effect on high blood pressure. The action of the tablets begins 5 minutes after ingestion. If the medication was taken in the form of capsules, then the action comes a little later.

But again, lowering blood pressure is not the main function of the drug, so hypertensive patients need to be careful with its intake. It does not always help to improve well-being, so you need to resort to the remedy in extreme cases.

When it reduces

"Nitroglycerin" is not among the recommended drugs for hypotensive patients. Therefore, in order not to worsen the state of health even more, it is recommended to refrain from taking the drug. Instead, it is advisable to take a tincture of ginseng, eleutherococcus, or Chinese magnolia vine, or drink a cup of coffee beans.

It is not contraindicated to take the remedy at high pressure, but it is also undesirable to do it yourself without consulting a doctor. Tablets of the remedy lower the abnormally increased pressure in 3-5 minutes. With increased blood pressure, it is recommended to take the drug in the form of a spray or tablets.

Side effects

The drug is released in several forms. The most common are tablets. Pills white color. The shape is flat-cylindrical, the surface of the drug is slightly rough to the touch. In addition, "Nitroglycerin" is also produced in the form of a sublingual spray. Spray transparent. In pharmacies, it is sold in bottles or cylinders.

The active ingredient of the drug is nitroglycerin. In addition, the composition of the drug includes sucrose, potato starch and glucose. "Nitroglycerin" is absorbed into the blood, and after a while the person feels better.

The composition of the sublingual spray also includes nitroglycerin as the active substance and ethanol. The spray does not contain additional substances, unlike tablets.

Constantly taking the drug is contraindicated. Over time, it is addictive and has no effect on well-being. In order to avoid the development of complications between the courses of "Nitroglycerin" you need to pause for one or two months. When taking tablets for the first time, you must first take half the dosage. If an allergic reaction or other side effects do not follow, then "Nitroglycerin is suitable" to eliminate seizures.

In case of an overdose of medication, you need to urgently call an ambulance. The first signs of an overdose are a decrease in pressure below 90 mm Hg. Art., also develops tachycardia, nausea or even vomiting, dizziness, weakness, confusion, drowsiness, fever.

When it reduces

Pregnancy and the period of breastfeeding.
Hypersensitivity to the active components of the drug.
Cranial hypertension.
Heart failure.
Collapse.
Previous head trauma (that happened recently).
Glaucoma.
Hypovolemia.
Pulmonary edema caused by toxic exposure.
Hyperthyroidism.
Anemia in severe form.
Patients under 18 years of age.
Arterial hypotension.
Circulatory disorders in the brain.
We will take drugs that increase potency in men.

Often taking the drug causes side effects, including:

dizziness;
allergic reactions;
headache;
violation of visual function;
muscle weakness;
flushed face;
pressure surges;
diarrhea;
vomit;
nausea;
dry mouth.

Uncontrolled use of medications without the permission of a doctor can lead to serious complications, up to the development of a myocardial infarction with a sudden death.

It is not recommended to take Nitroglycerin and Heparin together. If you take the drug in conjunction with such groups of drugs as antihypertensives, tricyclic antidepressants, MAO inhibitors, calcium antagonists, ethanol, vasodilators, then it is possible to increase the hypotensive effect of Nitroglycerin.

Joint reception with "Dihydroergotamine" leads to the fact that the level of nitroglycerin in the blood rises, thereby contributing to an increase in pressure. Especially careful in this case, you need to be hypertensive. A sharp increase in blood pressure negatively affects health in general and leads to irreversible consequences in some cases.

Keep "Nitroglycerin" out of the reach of small children. It is not recommended that the product be exposed to open sunlight. The storage location should be dark and well ventilated. Then the shelf life of the drug will be longer. And due to the lack of sunlight, the active substances that make up the composition will not be destroyed.

In any case, whatever the reason for taking Nitroglycerin, its combination with other medications is recommended only after consulting a doctor. Self-administration of this remedy can be very dangerous.

Their price is quite affordable, but in ampoules the drug is more expensive than in other forms.

"Nitroglycerin" is produced in different forms:

sublingual tablets (dosage 0.5 mg, 20, 40 pieces);
capsules (the dosage is the same as for tablets, in addition to the main substance, it contains 1 mg of a 1% oil solution);
1% alcohol solution, used as drops (volume 5, 10 ml);
sublingual spray (1 dose - 0.4 mg);
concentrate for solution preparation and intravenous administration (1 mg/ml, volume of ampoules 2, 5, 10 ml);
prolonged-release tablets (coated);
patch;
ointment.

Excellent medicine to help the heart muscle cope with excessive stress

Nitroglycerin (a group of nitrates) quickly found use. It began to be used at the end of the 19th century, after the discovery by the Italian Ascanio Sobrero. At first it was the production of explosives.

After a long observation of workers in the shops for the production of explosives, physician Merrill concluded that nitroglycerin vapors have an effect on human health.

A little later, it was found that this substance can also be used for medical purposes for the treatment of certain diseases. For example, after taking it is possible to remove the spasm of the heart vessels. With angina attacks, a few drops of the drug were enough to stop it.

So gradually nitroglycerin began to be used in medical practice.

Today, if you ask any person about (amp)#8220;Nitroglycerin(amp)#8221;: (amp)#8220;What is it for? (amp)#8221; seizures. No other medicine has yet been invented that would so quickly relieve the pain of angina pectoris.

(amp)#8220;Nitroglycerin(amp)#8221; can be attributed to those grandiose discoveries in the world of pharmacology, which happen infrequently. During its use, and this is already more than 100 years, a more effective cure for "angina pectoris" has not been invented.

Manufacturers produce its various forms and packaging, but the active ingredient remains the same. Now in pharmacies you can find a fairly large assortment. (amp)#8220;Nitroglycerin(amp)#8221; It comes in the form of tablets to be placed under the tongue. This is the very first form of release of the drug.

Now the nitroglycerin patch has become fashionable, which is enough to stick to the skin or mucous membrane for the active substance to begin its healing work. Even more advanced is (amp)#8220;Nitroglycerin Aerosol(amp)#8221;. Despite the fact that all these preparations contain the same substance, their cost can vary widely.

Many people are probably wondering what is the secret of such an instant effect of this medicine in heart attacks. The whole answer lies in the principle of the drug. Pain in angina occurs as a result of an acute oxygen deficiency in the heart muscle. There are only a few ways to remove it:

Increase the flow of oxygen to the heart.
Decrease heart rate and force to reduce oxygen consumption.

All this is quite capable of (amp)#8220; Nitroglycerin(amp)#8221;. After taking it, the production of nitric oxide increases, which dilates blood vessels, especially veins. This leads to the fact that the flow of venous blood to the heart muscle decreases, and the frequency of contractions and their strength decrease. If there is less work, then less oxygen is required.

But medicine(amp)#8220;Nitroglycerin(amp)#8221; it also increases the supply of oxygen to the heart due to the expansion of the coronary vessels, and this occurs more strongly at the site of ischemia, which leads to a rapid relief of an angina attack.

The effect of taking the medicine can be observed after a few minutes. The drug is also quickly expelled from the blood. After 40-45 minutes, there will be no trace of him.

There are a number of conditions for which (amp)#8220;Nitroglycerin(amp)#8221; is recommended. The application may require a one-time or long-term application. Among the indications are the following:

Any manifestations of angina pectoris.
Spasm of the coronary vessels, which may complicate intravascular studies.
Myocardial infarction, especially against the background of hypertension.
Heart failure.

(amp)#8220;Nitroglycerin(amp)#8221; may be used before neurosurgery. The use of it will artificially reduce the pressure.
Spasm of the arteries in the retina of the eyeball.
Dyskinesia of some parts of the digestive system.

It turns out that this medicine can be used not only in moments of heart pain, but also in some other cases. For example, to prevent an attack, if you have physical work to do or emotional stress is foreseen.

It is often taken by patients diagnosed with (amp)#8220;angina(amp)#8221;when climbing the stairs to the top floor of a high-rise building. It is recommended to take it before climbing the mountain, especially in winter, frosty and windy weather.

You should not be surprised if a doctor prescribes (amp)#8220; Nitroglycerin(amp)#8221; for attacks of pancreatitis or biliary colic. The prescription is in Latin, but the pharmacists in the pharmacy are well versed in such records. This appointment can be explained by the fact that this drug perfectly relieves spasm of the smooth muscles of the gastrointestinal tract.

Despite the great popularity of this drug, it must be remembered: it is still a medicine, so it must be taken according to certain rules. Only then can security be guaranteed.

The most efficient and fast way help is a tablet (amp)#8220; Nitroglycerin(amp)#8221; placed under the tongue. Since there are many blood vessels in the oral cavity, the medicine is almost instantly absorbed into the blood, and relief comes.

If you decide to take a pill (amp)#8220; Nitroglycerin(amp)#8221;, then before that it is better to sit down. Some may feel dizzy, and in exceptional cases, there are fainting spells.

In old age, it is better to take it in the supine position. At the time of the attack, the pill should work in a couple of minutes. If the pain does not let go, then you can take another one. If after 15 minutes the pain does not go away, then you will have to call a doctor, otherwise it is not far from myocardial infarction.

If in your first aid kit (amp)#8220;Nitroglycerin(amp)#8221; in the form of drops, then during a heartache, you can drop 2-4 drops on a piece of sugar and keep it under the tongue until it dissolves. Some manage to drip directly onto the tongue or even lick the vial from the cork.

Features of the drug

Nitroglycerin drugs are used for angina manifestations, when high blood pressure leads to spasms in the chest. However, it is recommended to prevent possible attacks with increased pressure before the upcoming psychological or physical stress with the risk of pain.

Nitroglycerin is advised to use five minutes before leaving the house in frosty weather, before conquering mountain peaks, training and sports activities.

Seizures

As a supplement, it is worth noting that nitroglycerin preparations can relieve spasms of the muscles of the digestive organs and bile ducts, relieve the tension of the sphincters of the bile duct. Due to these features, it is allowed to use these drugs in case of abdominal colic associated with biliary pathologies, pancreatitis, intestinal dyskinesia.

With increased vascular pressure, it is important to take into account certain rules for the use of nitroglycerin so that therapy gives desired effect and did no harm.

Tablet

If pain in the heart occurs during psychological or motor stress, and their duration is more than 2 minutes, it is recommended to put half or a whole tablet in the mouth until it dissolves.

The capsules of this drug are used in the same way. They dissolve rather quickly, due to which the substance soon appears in the blood. Therefore, the therapeutic effect begins within a few minutes after ingestion, and it lasts 30 minutes.

Before taking the drug, it is better to sit on a chair. The fact is that nitroglycerin can cause dizziness, and sometimes fainting. Older people are advised to dissolve the tablets in a supine position.

When there is pressing pain in the chest at rest, the patient should take the remedy in the same way. If the pain does not leave him for more than two minutes after taking the medicine, then the drug can be used again every 15 minutes, but not more than 3 times. If this does not help, it is worth calling an ambulance, since long-term symptoms of angina pectoris can be a sign of a heart attack.

If the drug is taken for the first time, it is better to take half a nitroglycerin tablet or capsule first to make sure that there is no sensitivity to the active ingredient. The same dose is recommended for elderly people who often faint.

Does liquid nitroglycerin reduce blood pressure? The drug in drops reduces pressure even more effectively. For the purpose of therapy, you need to apply three drops of the drug to a sugar cube and put it in your mouth under the tongue, and wait until the piece is completely dissolved. Sometimes medicine is immediately dripped onto the sublingual region from the cork, but here you should be careful not to overdose.

Resorption of the drug

Reception of nitroglycerin is possible only on the advice of a doctor. If treated on their own, especially in the form of drops, then you can easily exceed the allowable dose. As a result, the patient's blood vessels will expand sharply, pressure will drop, weakness and nausea will appear. In many people, when using nitrates, the skin is paler, the mucous membranes dry out, and uncomfortable feelings appear in the abdominal region.

Manifestation of an overdose

To prevent such a syndrome, it is necessary to responsibly follow the recommendations of the doctor, observing the doses and frequency of administration with accuracy.

In general, nitroglycerin is effective, and sometimes completely irreplaceable. But he also has his shortcomings. If the patient has a high sensitivity to this remedy, his condition instantly worsens, pressure drops, fainting occurs. Therefore, you need to start taking nitroglycerin with a small dose, eventually increasing it to the required amount. Often this drug is prescribed in combination with other medicines: validol or menthol.

There is another unfavorable point - nitroglycerin can cause constipation in adults and elderly patients. To solve such a problem is simple - drink laxative infusions or tablets.

To compensate for the negative effects of nitroglycerin preparations, Votchal drops were created. In their composition, in addition to directly nitroglycerin, there is menthol ether and lily of the valley tincture. This combination of components provides better tolerability of the drug. Menthol helps to neutralize headaches that appear as a side effect after nitroglycerin enters the bloodstream.

To understand whether it is possible to take nitroglycerin at low or high pressure, it is worth studying the instructions. In fact, the list of ailments in which the use of the drug is prohibited is not so wide. But it includes dangerous diseases:

Increased intracranial pressure, since the use of nitroglycerin can provoke cerebral hemorrhage;
Acute heart attack, as the medicine quickly and strongly lowers the pressure in the vessels;
Pregnancy or breastfeeding, as nitrates can have a negative effect on the baby;
Pulmonary edema;
In pediatric treatment, this drug is strictly prohibited.

Since nitroglycerin is an unstable substance that can deteriorate under the influence of temperatures and the sun, it is stored in a refrigerator. In this case, tablets or drops must be in their original packaging. If we talk about drops, then you need to leave them in the same vial in which you bought the drug at the pharmacy.

If the patient is going to use the drug infrequently, then it is best to choose nitroglycerin in the form of tablets or capsule plates, which are stored longer than drops.

This medicine is also sold in the form of an aerosol. It is convenient to store and use, especially in emergency situations.

There are a number of diseases in which "Nitroglycerin" is prescribed. Its use can be both long-term and one-time. The main target of the drug is the cardiovascular system.

However, in addition to heart disease, the drug is used for:

biliary colic;
acute pancreatitis;
spastic colitis;
intestinal dyskinesia;
spasm of the arteries in the retina;
pulmonary edema.

It is prescribed in the treatment of cardiovascular diseases:

angina pectoris, for the relief of pain in the chest;
heart failure;
hypertensive crisis, accompanied by pain in the heart;
acute ischemic necrosis;
neurosurgical operations to artificially lower blood pressure.

In addition, the drug can be used as a prophylaxis to reduce the risk of developing angina pectoris caused by stress or physical activity.

Nitroglycerin relieves not only heart pain, but also eliminates spasms of smooth muscles of the gastrointestinal tract

tablet - about 5 mg;
alcohol solution - 2-3 drops;
aerosol - 1-2 doses.

As a prophylaxis for an angina attack:

tablets - 0.5 mg a couple of minutes before going outside, starting physical activity;
spray - 1 dose, 5-10 minutes;
use the patch on the chest or upper arm (it is recommended to change the area the next time the patch is applied);
ointment - apply a thin layer of 5-10 cm on the skin of the chest, abdomen of the hands (repeat 2-3 times a day).

With myocardial necrosis, administer the drug intravenously (5% solution).

To eliminate pulmonary edema:

aerosol - 4 doses;
intravenously (1% solution).

For pancreatitis, hepatic colic, use 1 dose of the tablet form of the drug.

The drug is not used for myocardial infarction, glaucoma, during pregnancy and breastfeeding

Individual intolerance to drugs containing nitrates.
Age (up to 18 years).
Pregnancy, breastfeeding.
Low pressure.
Circulatory disorders.
Simultaneous use of phosphodiesterase inhibitors.
Collapse.
Violation of the functionality of the liver and kidneys.
Pulmonary edema due to exposure to toxins.
Heart disease.
Angle-closure glaucoma.
Epilepsy.

When using the drug "Nitroglycerin" side effects are possible:

dizziness;
headache;
pain in the stomach;
tachycardia at low pressure;
diarrhea;
nausea;
feeling of anxiety;
disorientation;
sensation of heat;
noise in ears;
dry mouth;
allergic reaction;
cyanosis (cyanosis of the skin and mucous membranes).

The substance dilates the blood vessels, because of this, the patient may experience a headache after taking it.

"Nitroglycerin" is a fairly common remedy. The drug has a fast action and is able to lower blood pressure for a short time.

Some rules for the use of "Nitroglycerin" for hypertension should be taken into account:

It is necessary to use the drug to lower the pressure while lying down or sitting (due to the rapid expansion of blood vessels, dizziness, fainting may occur).
To prevent addiction and reduce the effectiveness of the drug, it is necessary to take breaks in its use.
During the use of "Nitroglycerin" it is necessary to refuse to drink alcoholic beverages.
Since the drug has a synergistic effect, with prolonged lack of clarity of vision, as well as the manifestation of dry mouth, use should be suspended.
The drug affects the ability to drive a car, mechanisms.

You can take "Nitroglycerin" only as directed by a doctor (when an accurate diagnosis is established), who will prescribe the necessary form of the drug and its dosage.

Originally posted 2018-05-03 14:34:50.

One of the main issues in prescribing a medication such as nitroglycerin by a doctor is indications for use with high blood pressure. According to its effect on the body, the drug is characterized by an effective fight against angina pectoris and is prescribed when spasms of the heart vessels occur. Medicine recommended:

with pulmonary edema;
the occurrence of a heart attack in an acute form;
heart failure is one of the indications for medication;
acute form of pancreatitis;
angina.

Patients who have hypersensitivity to the components of the drug may feel a deterioration in their health. In this case, there is a decrease in blood pressure, dizziness begins and the heart often beats or a fainting state occurs.
Elderly people are recommended to use the drug with "Validol" or menthol.
In exceptional cases, taking the drug may cause stool retention. To do this, they additionally take buckthorn bark, senna leaves, Guttalax and other means to normalize bowel function.

Side effects and contraindications for use

By itself, nitroglycerin, which was obtained in 1847, is a chemical substance in the form of an ester of nitric acid and glycerol. At the time, the English physician Merill drew attention to the medicinal qualities of the substance; he noticed the special effect of nitroglycerin vapor on the health of workers involved in the production of explosives.

Thus, it was found that nitroglycerin is an effective drug that can be taken for spasms of the heart vessels.

Attacks of angina pectoris with the help of this substance quickly stop after taking one or two drops of the medicine, which was dripped on the patient's tongue. Gradually, nitroglycerin was recognized as a drug that temporarily lowers high blood pressure.

Today, such a well-known drug as Nitroglycerin has positive reviews, it is widely used by patients with coronary heart disease to quickly relieve pain with high blood pressure. The medicine anesthetizes quickly enough, and after 45 minutes this substance is completely eliminated from the body.

When is Nitroglycerin taken?

Nitroglycerin can be taken for angina when high blood pressure causes pain in the chest area.
It is also used for prophylactic purposes to prevent a possible attack with increased pressure before physical or emotional stress that provokes pain in the chest. Therefore, Nitroglycerin can be taken three minutes before going outside in the cold season, before climbing stairs or on a mountainous hill.
Additionally, nitroglycerin is able to relieve spasms of the smooth muscles of the gastrointestinal tract and biliary tract, relax the sphincter area of the bile duct, so it can be taken in case of biliary colic, acute pancreatitis, spastic intestinal dyskinesia.

With increased pressure, it is important to follow certain rules for using the drug so that the treatment is effective and safe.

When pain in the region of the heart appears during emotional or physical exertion and lasts more than two minutes, a whole or half tablet of the drug is placed under the tongue. Similarly, you can use one capsule of the drug.

Nitroglycerin is quickly absorbed, as a result of which the substance enters the bloodstream. Therefore, the therapeutic effect occurs literally in a minute and a half and lasts about 25 minutes.

When chest pain appears, if the person is at rest, Nitroglycerin can be taken in a similar way. If the pain does not recede for more than two minutes after taking the medicine, the drug is used every five minutes no more than three times.

If the pain continues, you should call an ambulance, as a prolonged attack of angina may indicate a myocardial infarction.

When taking Nitroglycerin for the first time, half a tablet should be used to exclude hypersensitivity to the drug. The same dosage is recommended for older people prone to fainting.
Nitroglycerin is also used at elevated pressure in the form of drops. For medicinal purposes, two to four drops of the drug are applied to a piece of sugar and kept in the mouth in the sublingual region until completely dissolved, without swallowing.
Alternatively, two to three drops of Nitroglycerin are applied to the tongue or sublingual region. Including, you can lick the medicine directly from the cork to avoid overdose.

Despite the effectiveness of the drug, it can be taken only after consultation with the doctor, since self-medication is fraught with an excess of the dosage of the drug. This, in turn, greatly reduces blood pressure, due to which a collapse can occur, a person feels weakness, nausea, the skin and mucous membranes turn pale.

Despite the indisputable advantages of the drug, Nitroglycerin has numerous disadvantages. People who are particularly sensitive to this chemical may experience a worsening condition, as the drug dramatically lowers blood pressure. In this case, the heartbeat becomes very frequent, the head hurts and is dizzy, the patient is in a pre-fainting state.

To avoid such consequences, older people are advised to take the medicine in a sitting position. Also, the drug should be used in minimal quantities, gradually increasing the dose. To mitigate side effects, Nitroglycerin is combined with menthol or Validol.

Sometimes the medicine can cause constipation, especially in older people. In this case, the usual well-known laxatives in the form of buckthorn bark, senna leaves, Bisacodyl, Gutalax can help. It is also recommended to eat cabbage, beets, apples, prunes, kefir and other foods rich in fiber.

As an alternative to the drug, you can take Votchal drops, which include menthol, nitroglycerin, belladonna tincture and lily of the valley. This combination improves the tolerability of the drug, while menthol reduces headaches and a feeling of fullness of the head when Nitroglycerin acts on the body. In this form, the drug should be taken ten drops at a time.

Contraindications include the following types of pathologies and diseases:

High intracranial pressure;
Hemorrhage in the brain area;
Myocardial infarction, when the drug sharply lowers blood pressure;
Glaucoma.

Since Nitroglycerin is able to quickly break down under the influence of light and heat, store it in the refrigerator. It is important that the medicine is only in the vial in which it was bought at the pharmacy. The fact is that containers and cotton wool are treated with a special substance that reduces absorption.

When the drug is opened, the medicinal properties are lost quickly enough, even if you follow all the storage rules. After two months, the effectiveness of the drug is reduced by 30 percent. Therefore, it is best to use Nitroglycerin in the form of tablets or capsules.

However, tablets should also be stored properly. Some patients prefer to take a printed medicine with them, wrapping it in paper. Meanwhile, there is no effect from such a medicine.

If the drug is used only once in emergency cases, it is ideal to buy a special spray at the pharmacy that can be stored for a long time. Also, this drug is rapidly absorbed.

A few rules to keep in mind:

Headaches when you first take the medicine are caused by the fact that the blood vessels dilate, that is, the drug begins to act. After a few days of using Nitroglycerin, this condition disappears, but this does not mean at all that there is no effect on the body. For this reason, under no circumstances should the dosage be increased. Long-acting drugs also often cause headaches.
With angina, you need to carry the medicine with you. When attacks appear, Nitroglycerin is taken immediately. The person must be in a sitting or lying position.
Five to six hours after taking the drug, the heart may begin to "whine". This is due to the fact that the dosage of the long-acting drug is enough for a given period of time, after which the heart begins to function independently, without any support. Because of this, the heart begins to make itself known. To avoid pain, the next pill is taken in advance for a few minutes.
If the pain does not stop after taking one tablet, after 15 minutes you can put another capsule under the tongue. It is necessary to observe the dosage so as not to cause complications. For prolonged pain, you should call a doctor.
It is important to know that the red capsules of Nitroglycerin contain an oily solution, so this medicine, due to the gradual absorption into the blood, lowers blood pressure very slowly. In this regard, with an attack of angina pectoris, there is no need to use capsules, it is better to use other dosage forms that quickly affect the body.

When Nitroglycerin is taken for more than a month, addiction can develop, due to which the drug loses its effectiveness. Therefore, you need to take a break for 30 days, after which it is allowed to re-treat. To avoid addiction, the medicine should be taken at a certain interval - at 7:00, 13:00 and 18:00.

People with low blood pressure or those with frequent low blood pressure should take Nitroglycerin with caution. Otherwise, the medicine will cause a headache, severe weakness, dizziness.

If the patient has had a stroke or has glaucoma, you should not take the drug without consulting your doctor.

In some cases, after prolonged use of the drug, the patient's visual functions may be upset. When a person looks at a dark image in a light background, yellow circles appear in the center of the eyes, and blue circles around the edges.

Nitroglycerin is available in the form of tablets, capsules, drops, spray and ampoules. The price of this drug is quite low and does not exceed 100 rubles, the only exception is ampoules, the cost of which reaches 500 rubles.

The chemical, which belongs to the large group of nitrates, is used as the basis for the development of all kinds of long-acting drugs. These drugs are used to prevent angina attacks.

The most famous drugs are Nitrong, Erinit, Sustak, Nitrosorbit. They are recommended to be taken in advance, before going outside in cold and windy weather, as well as on the eve of physical and emotional activity.

Such funds have positive customer reviews, but are able to prevent angina attacks for three to six hours, so they are much superior to pure Nitroglycerin. At the same time, the drugs have practically no side effects.

According to its effect, the effectiveness of the drug is due to the expansion of blood vessels, which may be accompanied by a slight headache in the patient. Taking the medication for several days is characterized by the cessation of pain.
If the patient is diagnosed with angina pectoris, then the patient should always have nitroglycerin with him, since attacks of high blood pressure can occur at any time.
A feature of the long-acting drug, which is nitroglycerin, is that the work of the heart should normalize during the duration of the drug. This is approximately five to six hours after ingestion. The characteristic "whining" of the heart is a sign that the use of the medicine needs to be repeated.
In the case when pain in the heart continues after taking a tablet or capsule of nitroglycerin, in order to exclude an overdose of the drug, it is best to seek help from a doctor.

With hypertension, you need to take the drug after examination by a cardiologist.
To lower blood pressure after taking the pills, you can not stand for some time. Often, after taking the remedy, a person begins to feel dizzy, and he may fall. Therefore, you need to sit down or better lie down and try to relax.
Blood pressure will return to normal, even if the heart hurts, but you need to take the drug in an amount of no more than 3 tablets at a time.
Older people and those with poor health should take half a tablet. Hypertensive patients are advised to coordinate medication with a cardiologist.
It is impossible to combine taking medicines with drinking alcoholic beverages. The interaction of the active components of the drug and alcohol causes severe poisoning of the body.

Nitric acid;
glycerol.

with pain in the chest or angina attacks;
for the purpose of preventive measures in case of possible stressful situations or depressions, the consequences of which are pain in the chest area;
in the event of spasms of the stomach and duodenum, as well as to expand the bile stream.

Capsules: 1 medication to bite and lay under the tongue.
Tablets: Place 0.5 of the drug under the tongue until completely dissolved.
Alcohol solution: 2 drops drip under the tongue or moisten a sugar cube and dissolve.
The spray is sprayed under the tongue.

Since, at elevated pressure, the active substances of the drug can provoke bouts of dizziness and loss of consciousness, before taking a pill, you should sit down or lie down on the sofa.
If the heart has not stopped hurting, you can take nitroglycerin again, but not more than 3 tablets at a time.
For elderly and debilitated people with reduced pressure, the dosage should be reduced to 0.5 tablets. Hypotension patients should coordinate in advance the possibility of taking the medication with the attending specialist.
During treatment with nitroglycerin, the use of alcohol is excluded. Alcohol and the active substance of the drug react and provoke severe intoxication of the body.
If the medication is caused by the prevention of angina pectoris before hard physical work, the tablet should be taken half an hour before receiving the load.

Indications for the use of the drug "Nitroglycerin" with increased pressure

High blood pressure nitroglycerin is sometimes taken as a spray. However, this dosage form has practically no advantages: it is explosive, makes it difficult to accurately dose, and is more expensive.

Nitroglycerin derivatives can be used to prevent angina attacks. The difference between these drugs is that they are absorbed more slowly, but give a prolonged effect. They are not placed under the tongue, but swallowed with a small amount of water.

Prevention is advisable if angina attacks are observed more often than once a day. Perhaps a single use of the drug for prophylactic purposes before public speaking, physical activity or sexual intercourse.

Unfortunately, problems with pressure, heart disease - which occur in our country quite often not only among the elderly, but also among other age categories of the population. The disease is “getting younger”, and more and more often you can meet athletes, young guys and girls who suffer from coronary diseases.

Doctors in cases of hypertension may prescribe medication, which is based on the use of such drugs:

To normalize cardiac activity, restore the normal level of the heart, the use of -adrenolytics is recommended.
Diuretics help to remove toxins and fluids from the body.
The action of ACE inhibitors is aimed at restoring the rinin-angiotensin system.
Alpha-drenoblockers restore the elasticity of blood vessels by blocking impulses.
Angiotensin receptor blockers reduce the effects of angiotensin.

In cases of problems with blood pressure, the work of the cardiovascular system, doctors use, depending on the symptoms and individual tolerance of the components of medicines, doctors prescribe several types of drugs. Among the most popular medications are the following:

Valerian tincture contains isovaleric acid, borneol ester, alkaloids and valeric acid. Its action is aimed at normalizing sleep, restoring the nervous system, helps with spasms of the gastrointestinal tract;
No-shpa with pressure is prescribed by doctors in cases where patients need to relieve spasms, in some cases, hypertensive patients are recommended to use just such a drug to reduce headaches;
Papazol is also considered an antispasmodic and its action is aimed at lowering blood pressure. Doctors prescribe this drug to people who develop hypertension based on peripheral vasospasm;
Pressure nitroglycerin is one of the most sought after antianginal drugs. Effective effect on spasms of smooth muscles, lowering blood pressure, improving heart rate.

Of course, these are the most popular drugs, but there are a number of other medications that are similar in their effect to the above drugs.

A feature of the drug is that it dissolves quickly, so it quickly enters the bloodstream and begins its effect on the vessels and the cardiovascular system.

The dosage of the drug does not change even with an increase in pressure in a person who is in a state of peace of mind.

However, a number of specific rules for the use of the drug should be observed:

Oral high blood pressure nitroglycerin is best taken while sitting. During the activation of the remedy, dizziness may occur, it is necessary not to omit the occurrence of fainting in the patient;
If the pain does not go away within 15 minutes, the intake of nitroglycerin must be repeated at the same dosage, but not to exceed three tablets in 15 minutes;
When taking the drug for the first time, it is better not to exceed the dose of half a tablet. This will help to check the individual tolerance of the drug. Older people are not recommended to take more than 1⁄2 tablets at a time. This is due to the possibility of fainting;
If you have a drug in the form of drops, it is best to take it this way: drop 1-2 drops on a piece of refined sugar and dissolve in your mouth. Or drop 2 drops of the solution on the tongue.

It should be remembered that it is not necessary to independently determine the dose of nitroglycerin. Only doctors can prescribe treatment with this medication. An overdose of the drug can cause collapse, which can manifest itself in symptoms such as nausea, loss of consciousness, blanching of the skin and mucous membranes.

To cope with bouts of pain, the tablet is sucked. You can not swallow the drug. Dissolve "Nitroglycerin" until completely dissolved in the mouth. Take the remedy immediately after the onset of pain. If relief does not come after 5-10 minutes, you need to take another one.

The spray is also used under the tongue. For one dose, you need to press the valve 1 time so that the spray is sprayed in the mouth. Within 15 minutes, you can not use more than 3 dosages. If after 3 clicks the pain does not go away, then the remedy in this case is ineffective.

If a person cannot open his mouth on his own during an attack, he needs help and gently put a pill under his tongue or spray it with a spray.

Today, the drug has an unprecedented popularity, because the result after its use is achieved incredibly quickly, and after 45 minutes it is completely eliminated from the body.

So that the result of the treatment is not long in coming, and at the same time there is an effectiveness in improving well-being, it is necessary to follow some recommendations for taking the medication.

an attack of angina pectoris, which is acute;
ischemic myocardial necrosis;
violations of the functions of the heart muscle;
swelling of the lungs;
during a hypertensive crisis;
to ensure the patency of the biliary tract and intestinal tract;
with increased intracranial pressure;
pancreatitis in acute or higher stage;
to reduce pressure during neurosurgical operations.

But at the same time, it is unnecessary to make a diagnosis on your own, you should consult a specialist, and only after the laboratory tests have been carried out, the doctor will decide whether to prescribe the drug or not.

To begin with, it is worth checking for the presence of allergic reactions to the components of the drug. Therefore, the first time you need to drink only half the dose of the pill, while it is best for older people to use the remedy in this amount.
With high blood pressure, the drug is used as follows: dropping a small drop on a piece of sugar, put it under the tongue. Further, the cube gradually dissolves, and the components of the drug enter the bloodstream.
No more than 3 drops are recommended to drip directly under the tongue or lick a small amount of medication from the cork to avoid overdose.

Despite a number of advantages and positive qualities of Nitroglycerin, it should be taken strictly on the recommendation of a specialist in order to exclude the occurrence of possible side effects, including those associated with an overdose.

increased intracranial pressure;
hemorrhage in the brain;
heart attack;
glaucoma.

In any case, you can not reduce the pressure on your own, especially if there are contraindications. Sharply reducing the pressure, you can cause a deterioration in the condition.

The substance dilates the blood vessels, because of this, the patient may experience a headache after taking it, which soon disappears.
If the patient has a confirmed diagnosis of angina pectoris, the medicine should always be with you in the original packaging in case of an attack.
Long-term use of "Nitroglycerin" can be addictive. In this regard, before starting a second course of treatment with this medication, it is imperative to take a break of at least 30 days.
In no case should you use Nitroglycerin and alcohol at the same time. This can lead not only to serious consequences, but even to death.

Nowadays, experts are trying to develop a medicine that would stop the pain during angina attacks. But there is no substance that could fully replace Nitroglycerin. This is an excellent fast-acting remedy that can further lower blood pressure. Nevertheless, it is impossible to use "Nitroglycerin" as an independent drug to reduce pressure, because this can cause serious consequences.

To the questions: “Is it possible to take nitroglycerin at high pressure?”, “Nitroglycerin increases or lowers blood pressure?” there is an absolutely correct answer. Doctors recommend drinking "Nitroglycerin" precisely at high pressure, since the drug has a powerful vasodilating effect, which is used to eliminate angina attacks.

Attacks of angina pectoris.
Pulmonary edema.
Intestinal dyskinesia.
Acute pancreatitis.
Biliary colic.
Prevention.

The maximum intake of tablets and capsules for an adult is 1 or ½ - single, daily - 5 pieces. Alcohol solution - 4 drops, per day - 16 drops.

Before using the medicine, it is advisable to take a sitting or lying position, as the medicine causes dizziness.

The effect of nitroglycerin is preferably checked by measuring blood pressure every 15 minutes. In case the pressure has not decreased, it is allowed to drink 1 more tablet or 2 drops of the solution. The action of the drug occurs in 1-2 minutes and lasts about 20-30 minutes. It is not recommended to use nitroglycerin for more than a month, as the drug can be addictive, which will lose its effectiveness. In this case, you can replace the drug with an analogue, consult a doctor.

Angina pectoris and its prevention.
Necrotic foci in the myocardium (acute ischemic necrosis).
Heart failure.
With a hypertensive crisis and accompanying pain in the heart.

Precautionary measures

Those taking nitroglycerin regularly should consider two factors. Firstly, with constant use, the drug is addictive. Secondly, as the duration of therapy, the effectiveness of the active substance may decrease. This will require a constant increase in the frequency of medication.

When taking nitroglycerin for the first time, it is better to limit yourself to a half dose, so that in case of individual intolerance, the unpleasant consequences do not appear in full force.

If a person does not have sufficient experience with nitroglycerin in aerosol form, he may experience an overdose from pressing the spray head several times in a row. In an environment of increased stress or in conditions of panic given error is very likely, and since it is fraught with fainting, you should be especially careful with the aerosol form of release of the product.